| 100% | DRWHO | 5 | BBC classic whose title role will be played by a woman for the first time in 2017 |
| 42% | EMMA | 4 | 1815 classic whose title character is played by Anya Taylor-Joy in a 2020 film |
| 40% | SAUDIS | 6 | Women who were legally permitted to drive for the first time in 2018 |
| 39% | RADIO | 5 | It was used to play music for the first time in 1906 |
| 38% | THURGOOD | 8 | With 52-Across, Supreme Court justice who's the title role played by Chadwick Boseman in a 2017 biopic |
| 37% | JAMESBOND | 9 | British spy played by 33-Across for the first time in 48-Across (2 wds.) |
| 37% | KILLINGEVE | 10 | BBC America drama whose title role is an MI5 agent played by Sandra Oh: 2 wds. |
| 37% | FUNNYGIRL | 9 | Broadway revival whose title role will be played by Lea Michele |
| 36% | OSLO | 4 | 2017 Tony-winning play whose title is also the name of a Norwegian city |
| 36% | BSMITH | 6 | Transcultural icon whose home collection was the first by a Black woman to be sold at a major retailer |
| 35% | WARS | 4 | "Star ___," classic arcade game released by Atari in 1983 in which the goal is to survive for a set time from the shots fired by enemies |
| 34% | EHJOE | 5 | 1966 BBC TV play by Samuel Beckett starring Jack MacGowran in the title role |
| 34% | TRIB | 4 | Pub. whose editorial page endorsed a Democrat for president for the first time in 2008 |
| 34% | ASIA | 4 | Where the Olympics were held for the first time in 1964 |
| 34% | SAUDI | 5 | ___ Arabia (nation where women voted for the first time in 2015) |
| 34% | AUSTINBUTLER | 12 | "Once Upon a Time in Hollywood" actor who plays the title role in "Elvis" (2 wds.) |
| 34% | EVEL | 4 | First name of the role George Hamilton played in a 1971 movie where he stated "I am the last gladiator in the new Rome" |
| 33% | THEDOCTOR | 9 | Time Lord whose 11th incarnation was played by 15-Across on a long-running BBC sci-fi series: 2 wds. |
| 33% | WARNER | 6 | David —, actor who played the title role in 1966 comedy-drama film Morgan: A Suitable Case for Treatment |
| 33% | EVE | 3 | Woman who was tempted by a serpent in the Book of Genesis |
| 33% | AMYPOEHLER | 10 | Actress who played the role of Leslie Knope in "Parks and Recreation", a role she is best-known for: 2 wds. |
| 33% | BROMANTICCOMEDY | 15 | Modern-day genre for the 1952 film whose title is suggested by a word ladder starting at 1-Across |
| 33% | SHOWMETHEMONEY | 14 | Catchphrase shouted in "Jerry Maguire" ... whose start is a state nickname for the state indicated by the circled squares |
| 33% | PROTEM | 6 | For the time being, in some titles |
| 32% | HAPPY | 5 | 2011 song by Pharrell Williams whose title is also a word for being joyful and describes the emotion behind a smile |
| 32% | TOMLINSON | 9 | LaDainian ___, a running back who played for the New York Jets who was inducted into the Hall of Fame in 2017 |
| 32% | VASCOROSSI | 10 | Italian singer whose Enzo Ferrari Park concert in 2017 is the highest-attended ticketed concert for a single artist: 2 wds. |
| 32% | SHANE | 5 | Title role for Alan Ladd in a classic 1953 western |
| 32% | RALPHFIENNES | 12 | "The English Patient" actor, who plays officer Amon Goth in 33a, a role for which he was nominated for the Oscars: 2 wds. |
| 32% | THE | 3 | With 100-Down, 1951 horror film whose title role was played by James Arness |