| 100% | SPEND | 5 | Be the opposite of 4-Down |
| 72% | NADA | 4 | Opposite of 4 Down |
| 70% | NON | 3 | French word that is the opposite of 2-Down |
| 67% | NNE | 3 | Direction that is the opposite of SSW |
| 67% | YEAS | 4 | Votes that are the opposite of nays |
| 67% | ALKALINE | 8 | Batteries that are the opposite of acidic |
| 67% | ANTONYM | 7 | Word that is the opposite of another |
| 67% | ITALY | 5 | Where "caldo" is the opposite of cold |
| 67% | PRE | 3 | Prefix that is the opposite of "post" |
| 67% | NAYS | 4 | Negative votes that are the opposite of yeas |
| 66% | ACIDS | 5 | Caustic substances that are the opposites of bases |
| 66% | ANTONYM | 7 | A word whose meaning is the opposite of another |
| 66% | OUI | 3 | French word that is the opposite of 14-Across |
| 65% | LIGHT | 5 | It can be the opposite of either dark or heavy |
| 65% | UNO | 3 | Card game that looks like the opposite of 4-Across? |
| 65% | ANTAGONIST | 10 | The opposite of one who is not against? |
| 63% | GRIN | 4 | Expression that seems like it would be the opposite of 5-Across? |
| 63% | SOY | 3 | Kind of beans that are the source of 4-Down |
| 63% | UBER | 4 | Opposite of 4-Down |
| 63% | PRO | 3 | Opposite of 4-Down |
| 62% | BIZARROWORLD | 12 | DC Comics planet where things are the opposite of their equivalents on Earth |
| 62% | WIIPLAY | 7 | Nintendo party game (which sounds like it could be the opposite of 1-Across?) |
| 61% | BIBLE | 5 | With 4-Down, much of the Southeast U.S. is in it |
| 60% | DROOPY | 6 | __ Dog is the Debbie Downer of cartoons |
| 59% | FAILURE | 7 | Organ __ is the shut down of essential organs |
| 59% | BACKFIRE | 8 | To have the opposite effect of what was intended |
| 58% | CATCHPHRASE | 11 | Popular expression ... or what the opposite of the answer to each starred clue is? |
| 57% | ANAL | 4 | Felix's description, it being the exact opposite of Oscar Madison |
| 57% | HUMILITY | 8 | The quality of being down to earth and modest |
| 57% | ACROSS | 6 | In crossword puzzles, the opposite of "down" |