| 100% | NATIVESON | 9 | Best-selling 1940 novel that was adapted into a film, with its author playing the protagonist, in 1951 |
| 41% | HIGHFIDELITY | 12 | 50-Across novel that was adapted into a feature film in 2000, a Broadway musical in 2006, and a TV series in 2020 (2 wds.) |
| 41% | DAVIDMITCHELL | 13 | Author of the novel that was adapted into the 2012 film 7-/49-Across |
| 39% | INTERVIEW | 9 | "___ with the Vampire," 1976 gothic horror novel by Anne Rice that was adapted into a film starring Brad Pitt |
| 39% | FOX | 3 | "Fantastic Mr ___," 1970 Roald Dahl novel that was adapted into a 2009 Wes Anderson film |
| 38% | IKNOWWHATYOU | 12 | With 30-Across, Lois Duncan horror novel that was turned into a film in 1997: 4 wds. |
| 38% | BEES | 4 | "The Secret Life of ___," 2001 Sue Monk Kidd novel that was adapted into a 2008 film starring Queen Latifah |
| 36% | PYGMALION | 9 | Play written in 1912 by George Bernard Shaw that was adapted into the film "My Fair Lady" |
| 36% | DOLPHINS | 8 | "Island of the Blue ___," 1960 Scott O'Dell novel that was adapted into a 1964 James B. Clark film |
| 35% | MAME | 4 | “Auntie ___” (Patrick Dennis novel that was adapted into a musical) |
| 35% | DENNISLEHANE | 12 | Author of the 2001 novel "Mystic River" that was made into a 2003 Sean Penn film: 2 wds. |
| 35% | THEHATEUGIVE | 12 | Best-selling novel by 40-Across that was adapted into a new movie: 4 wds. |
| 35% | ITINA | 5 | Memoir that was adapted as the film "What's Love Got to Do With It" |
| 35% | EWANMCGREGOR | 12 | Actor who plays the protagonist in "Christopher Robin" which is a fantasy film based on "Winnie-the-Pooh": 2 wds. |
| 35% | ROAD | 4 | "The ___," 2006 novel by Cormac McCarthy that was adapted into a 2009 survival film |
| 35% | VENDETTA | 8 | "V for ___," graphic novel by Alan Moore about a dystopian future in the UK that was adapted into a Natalie Portman film |
| 34% | ARLO | 4 | Guthrie with a folk hit that was adapted into a 1969 comedy film |
| 34% | NICHOLASHOULT | 13 | Actor who plays the protagonist in "Jack the Giant Slayer," which is a fantasy film based on British fairy tales: 2 wds. |
| 34% | OLDMAN | 6 | *"The ___ and the Sea," 1952 novel by Ernest Hemingway that was adapted into a 1958 film: 2 wds. |
| 34% | CARRIE | 6 | 1974 novel by Stephen King that was adapted into a 1976 film starring Sissy Spacek |
| 33% | THEDRY | 6 | Novel by Australian author Jane Harper that was adapted into a movie starring Eric Bana: 2 wds. |
| 33% | TWILIGHT | 8 | 2005 novel by Stephenie Meyer featuring vampires that was adapted into a film series starring Robert Pattinson |
| 33% | AIDA | 4 | Opera that was adapted into a musical that opened on Broadway in 2000 |
| 33% | DARK | 4 | "The ___ Knight Returns," graphic novel by Frank Miller that was adapted into a film trilogy starring Christian Bale as Batman |
| 33% | STORYOFYOURLIFE | 15 | Ted Chiang novella that was adapted into the film "Arrival" |
| 32% | ALICE | 5 | "___ in Wonderland," 1951 Walt Disney film which ends with the titular protagonist waking up from a dream |
| 32% | WILD | 4 | "The ___ Swans," fairy tale by Hans Christian Andersen that was adapted into a 1977 Japanese anime film |
| 32% | SKATEBOARDING | 13 | Sport that will make its debut in the 2020 Olympics and involves riding and performing tricks on a narrow board with wheels |
| 32% | NIGHTFALL | 9 | 1941 sci-fi short story by Isaac Asimov that was adapted into a 1988 film starring Sarah Douglas |
| 32% | OUTER | 5 | "___ Dark," 1968 novel by Cormac McCarthy that was adapted into a 2009 short film |