| 100% | DEVI | 4 | Bidya ___ Bhandari, Nepalese politician who is the first woman to serve as the President of Nepal |
| 72% | SAHLE | 5 | ___-Work Zewde, Ethiopian politician who is the first woman to serve as the President of Ethiopia |
| 64% | MIA | 3 | ___ Mottley, Barbadian politician who is the first woman to serve as the Prime Minister of Barbados |
| 57% | JACINDA | 7 | ___ Ardern, New Zealand politician who is the youngest woman to serve as the Prime Minister of New Zealand |
| 51% | RENO | 4 | Janet who was the first woman to serve as U.S. attorney general |
| 49% | KAMALAHARRIS | 12 | Former California senator who is the first woman and first person of color to be inaugurated as vice president of the United States (2 wds.) |
| 44% | RETTON | 6 | Gymnast Mary Lou who was the first woman to appear on the front of a Wheaties box |
| 44% | JANETRENO | 9 | First woman to serve as attorney general of the US: 2 wds. |
| 43% | DOROTHYARZNER | 13 | “The Bride Wore Red” director who was the first woman to join the Directors Guild of America |
| 43% | JAMESMADISON | 12 | U.S. president who was the first to have served in the House of Representatives, the first to have an inaugural ball, and the first to wear long pants instead of knee breeches (2 wds.) |
| 43% | RENO | 4 | Janet, first woman to serve as the Attorney General of the United States |
| 43% | KWAME | 5 | ___ Nkrumah, Ghanaian politician who served as the first Prime Minister and President of Ghana |
| 43% | BEV | 3 | Politician Perdue who was the first woman elected governor of North Carolina |
| 42% | MICHELLEOBAMA | 13 | First African-American woman to serve as First Lady of the United States (2 wds.) |
| 41% | JOSEPHRBIDEN | 12 | Former vice president who is the oldest person to be inaugurated as president of the United States (3 wds.) |
| 40% | CAROLEKING | 10 | "You've Got a Friend" singer/pianist who was the first woman to win a Grammy for Song of the Year (2 wds.) |
| 39% | USN | 3 | JFK was the first president to have served in this branch of the US Armed Forces |
| 39% | ANNMEYERS | 9 | Basketball Hall-of-Famer who was the first woman to sign an N.B.A. contract |
| 39% | TINAFEY | 7 | Actress/writer who was the first woman to be head writer of "Saturday Night Live," and the third woman to host five times (2 wds.) |
| 39% | STEVIENICKS | 11 | American singer and songwriter who became the first woman to be inducted twice into the Rock and Roll Hall of Fame: 2 wds. |
| 38% | COURIC | 6 | Journalist who was the first woman to guest-host "Jeopardy!" |
| 38% | EDITHWHARTON | 12 | 13-Across and 25-Across writer who was the first woman to win a Pulitzer Prize in Literature, for her 1920 novel "The Age of Innocence" (2 wds.) |
| 38% | REBA | 4 | Singer McEntire who was the first woman to play Colonel Sanders |
| 38% | CURIE | 5 | Last name of the first woman to win the Nobel Prize and who is credited with the theory of radioactivity |
| 38% | THABO | 5 | ___ Mbeki, former politician who served as the second President of South Africa |
| 38% | JEN | 3 | Cartoonist Sorensen who was the first woman to win the Herblock Prize |
| 38% | ZAHA | 4 | Hadid who was the first woman to win the Pritzker Architecture Prize |
| 38% | KATIECOURIC | 11 | Journalist who was the first woman to guest-host "Jeopardy!" (2 wds.) |
| 38% | NAOMAMPBELL | 11 | *Woman who was the first Black model to appear on the cover of Time |
| 37% | EDITH | 5 | Wharton who was the first woman to win the Pulitzer Prize for Literature |