| 100% | BENNYGOODMAN | 12 | Big Band bandleader who was the first jazz bandleader to play Carnegie Hall (2 wds.) |
| 50% | SHERYLSWOOPES | 13 | Basketball Hall of Fame inductee who was the first player to sign with the WNBA: 2 wds. |
| 48% | LISALESLIE | 10 | Basketball Hall of Fame inductee who was the first player to dunk in a WNBA game: 2 wds. |
| 48% | ANDREAMCARDLE | 13 | Tony-nominated actress who was the first to play 40-Across on Broadway (2 wds.) |
| 47% | PATSYCLINE | 10 | American singer (birthday today) who was the first female solo artist inducted to the Country Music Hall of Fame: 2 wds. |
| 47% | RICKEYJACKSON | 13 | Former American Football linebacker (birthday today) who was the first Saints player elected to Pro Football Hall of Fame: 2 wds. |
| 47% | NEWYORK | 7 | The Big Apple, which is home to the Nesuhi Ertegun Jazz Hall of Fame: 2 wds. |
| 46% | MAHALIA | 7 | Jackson who was the first gospel singer to perform at Carnegie Hall |
| 46% | JACKIESTILES | 12 | 2016 Women's Basketball Hall of Fame inductee who was the first Division I player to score over 1,000 points in a season: 2 wds. |
| 45% | STEPHENSTILLS | 13 | American singer and songwriter who is the first artist to be inducted twice on the same night into the Rock and Roll Hall of Fame: 2 wds. |
| 45% | STEVIENICKS | 11 | American singer and songwriter who became the first woman to be inducted twice into the Rock and Roll Hall of Fame: 2 wds. |
| 44% | GLENNMILLER | 11 | Big Band bandleader whose recording of "In the Mood" is in the Grammy Hall of Fame (2 wds.) |
| 44% | MOMSMABLEY | 10 | Trailblazing African American who was the first female comedian to perform at the Apollo Theater: 2 wds. |
| 44% | AMELIAEARHART | 13 | Aviation pioneer who was the first woman to fly solo across the Atlantic: 2 wds. |
| 44% | JOHNMADDEN | 10 | Football player turned broadcaster who was the first one to have worked for all of the "Big Four" TV networks: 2 wds. |
| 43% | SEATTLESLEW | 11 | 1977 Triple Crown winner who was the first American champion to have been undefeated in previous races: 2 wds. |
| 43% | LEVARBURTON | 11 | "Reading Rainbow" host who was the first Grammy winner to guest-host "Jeopardy!" (2 wds.) |
| 43% | ETHELWATERS | 11 | Harlem Renaissance singer and actress who was the first African American to star in her own TV show: 2 wds. |
| 43% | SHERYLSWOOPES | 13 | Openly gay basketballer who was the first woman to be signed by the WNBA: 2 wds. |
| 43% | TENZINGYATSO | 12 | 14th Dalai Lama who was the first Tibetan to win the Nobel Peace Prize: 2 wds. |
| 43% | AARONRODGERS | 12 | Green Bay Packers quarterback who was the first NFL star to guest-host "Jeopardy!" (2 wds.) |
| 43% | FRANTARKENTON | 13 | Pro Football Hall of Fame quarterback who was the first pro athlete to host "Saturday Night Live," in 1977, two years after he was named the NFL MVP (2 wds.) |
| 43% | WARRENMOON | 10 | Undrafted quarterback who was the first African American quarterback inducted into the Hall of Fame: 2 wds. |
| 43% | YURIGAGARIN | 11 | Russian who was the first person to travel into space and orbit the earth (1961): 2 wds. |
| 43% | MUHAMMADYUNUS | 13 | Social entrepreneur and economist who was the first Bangladeshi to win the Nobel Peace Prize: 2 wds. |
| 42% | WALTERJOHNSON | 13 | Senators pitcher who was inducted in the first Hall of Fame ceremony: 2 wds. |
| 42% | IRA | 3 | Aldridge who was the first Black actor to play Othello |
| 42% | MARGARETCOURT | 13 | Australian tennis player who was the first woman to win the Grand Slam in the Open Era: 2 wds. |
| 42% | JOANRIVERS | 10 | Comedian who was the first woman to host a late-night talk show on a major network: 2 wds. |
| 42% | TRISSPEAKER | 11 | Indians center fielder who was inducted in the first Hall of Fame ceremony: 2 wds. |