| 100% | SPEED | 5 | Bomb-on-a-bus thriller starring Keanu Reeves and 49-Across |
| 54% | JOHNNYMNEMONIC | 14 | 1995 film starring Keanu Reeves, based on a short story by 44-Across: 2 wds. |
| 49% | SPEED | 5 | 1994 Keanu Reeves film set on board a bus |
| 48% | STRANGERS | 9 | "___ on a Train," 1951 thriller movie starring Farley Granger and Robert Walker |
| 47% | LAKE | 4 | "The ___ House," 2006 fantasy film starring Keanu Reeves and Sandra Bullock as two people who meet via letters in a time-defying mailbox |
| 46% | CRASH | 5 | Psychological thriller starring Don Cheadle and 49-Across |
| 46% | GRAVITY | 7 | Space thriller starring George Clooney and 49-Across |
| 46% | JOHNWICK | 8 | Neo-noir action thriller starring Keanu Reeves |
| 45% | DEMOLITIONMAN | 13 | Futuristic thriller starring Sylvester Stallone and 49-Across (2 wds.) |
| 45% | SPEED | 5 | 1994 movie starring Keanu Reeves and Sandra Bullock |
| 45% | SPEED | 5 | 1994 action film starring Keanu Reeves and Dennis Hopper |
| 44% | BROKEN | 6 | With 49-Across, it keeps repeating itself ... and, based on the first and last letters, an apt description of each answer to a starred clue |
| 44% | CHAIN | 5 | & 3D 1996 action film starring Keanu Reeves and Morgan Freeman |
| 44% | SWEET | 5 | & 17A 2001 film drama starring Keanu Reeves and Charlize Theron |
| 44% | STREET | 6 | 2008 crime drama film starring Keanu Reeves and Forest Whitaker |
| 44% | THESENTINEL | 11 | A 2006 crime thriller based on Gerald Petievich's novel, starring 18a and Michael Douglas: 2 wds. |
| 43% | THEMATRIX | 9 | 1999 action-sci-fi film starring Keanu Reeves and Laurence Fishburne |
| 43% | ASCANNER | 8 | &15A 2006 film animation starring Keanu Reeves and Robert Downey Jr |
| 43% | ATOMICBLONDE | 12 | 2017 spy thriller starring 49-Across and James McAvoy (2 wds.) |
| 43% | MATRIX | 6 | The —, 1999 action/sci-fi film starring Keanu Reeves and Laurence Fishburne |
| 43% | THEDANISHGIRL | 13 | Alicia Vikander and 49-Across film based on a David Ebershoff novel (3 wds.) |
| 43% | LESMISERABLES | 13 | Hugh Jackman and 49-Across film based on a Victor Hugo novel (2 wds.) |
| 42% | REACTION | 8 | "Chain ___," science fiction movie starring Keanu Reeves and Morgan Freeman released in 1996 |
| 41% | DEVILSADVOCATE | 14 | "The ___," horror movie starring Keanu Reeves and Al Pacino which released in 1997: 2 wds. |
| 39% | JOHNWICK | 8 | "___ : Chapter 3 - Parabellum," action thriller starring Keanu Reeves that was one of the biggest hits of 2019: 2 wds. |
| 37% | LONGMIRE | 8 | Western crime series on A&E starring Robert Taylor and Lou Diamond Phillips |