| 100% | NED | 3 | Boyfriend of the title character in "The Nancy Drew Files" |
| 53% | JAY | 3 | First name of the title character in "The Great Gatsby" |
| 53% | HAN | 3 | First name of the title character in "Solo" |
| 52% | NED | 3 | Nancy's boyfriend, in the Nancy Drew books |
| 51% | NED | 3 | Playable character in the Nancy Drew PC game Alibi in Ashes |
| 51% | DEPP | 4 | Actor Johnny who was the voice of the title character in "Rango" |
| 51% | SMIKE | 5 | Friend of the title character in 1839 Charles Dickens novel Nicholas Nickleby |
| 50% | LEA | 3 | Actress Salonga who provided the singing voice of the title character in "Mulan" |
| 50% | SMIKE | 5 | Close friend of the title character in 1839 Charles Dickens novel Nicholas Nickleby |
| 50% | DONN | 4 | Arabella —, wife of the title character in 1895 Thomas Hardy novel Jude the Obscure |
| 49% | UNCAS | 5 | Title character in the J F Cooper novel The Last of the Mohicans |
| 49% | ANTONIO | 7 | Title character in Shakespeare play The Merchant of Venice |
| 49% | JOSEPHCOTTEN | 12 | Actor who played a reporter and friend of the title character in 17-Across: 2 wds. |
| 48% | ANTONIO | 7 | Title character in William Shakespeare play The Merchant of Venice |
| 47% | MARS | 4 | Whence the title character of “Stranger in a Strange Land” |
| 47% | KEVINCOSTNER | 12 | "Field of Dreams" actor who starred as the title character in the 1990 film "Dances With Wolves": 2 wds. |
| 47% | DANIELKALUUYA | 13 | Actor who plays Slim, one of the title characters on the run in 2019's "Queen & Slim": 2 wds. |
| 47% | SUSANSARANDON | 13 | Actress who played Louise, one of the title characters on the run in 1991's "Thelma & Louise": 2 wds. |
| 47% | UNCAS | 5 | Title character in 1826 J F Cooper novel The Last of the Mohicans |
| 46% | ELF | 3 | 2003 film in which the title character exclaims "Son of a nutcracker!" |
| 46% | WARREN | 6 | With 35-Across, actor who played Clyde, one of the title characters on the run in 1967's "Bonnie and Clyde" |
| 46% | HANDL | 5 | Irene —, comedy actress who played the title character in 1970s ITV sitcom For the Love of Ada |
| 45% | HADES | 5 | 2020 video game in which Zagreus, the son of the title character, attempts to escape the Greek underworld |
| 45% | KWAN | 4 | Nancy —, actress who played the title role in films Tamahine and The World of Suzie Wong |
| 45% | HENCHARD | 8 | Michael —, hay-trusser; title character in 1886 Thomas Hardy novel The Mayor of Casterbridge |
| 45% | KATEY | 5 | With 35-Across, "Sons of Anarchy" actress who plays the title character in "Rebel" |
| 45% | PETERDINKLAGE | 13 | "Game of Thrones" actor who plays the title character in "The Toxic Avenger": 2 wds. |
| 44% | DOCTORWHO | 9 | BBC sci-fi series in which 31-Across plays the 10th and 14th incarnations of the title character: 2 wds. |
| 44% | CLYM | 4 | & 11D Paris diamond merchant; title character in 1878 Thomas Hardy work The Return of the Native |
| 43% | JAMESMCAVOY | 11 | "X-Men: Apocalypse" star who played the title character of 28-Across in a 2015 movie: 2 wds. |