| 100% | JERRYSEINFELD | 13 | Brooklyn-born comedian and namesake of a 1990s sitcom: 2 wds. |
| 63% | MARTINLAWRENCE | 14 | Stand-up comedian and star of a 1990s Fox sitcom, whose title was his first name: 2 wds. |
| 55% | LARRYDAVID | 10 | Brooklyn-born comedian and creator of "Curb Your Enthusiasm": 2 wds. |
| 54% | JOANRIVERS | 10 | Brooklyn-born comedian and host of "Fashion Police": 2 wds. |
| 54% | CYBILLSHEPHERD | 14 | "Moonlighting" actress and star of a 1990s CBS sitcom, whose title was her first name: 2 wds. |
| 53% | ELLENDEGENERES | 14 | Talk show host and star of a 1990s ABC sitcom, whose title was her first name: 2 wds. |
| 52% | FULLERHOUSE | 11 | Netflix reboot of a 1990s sitcom about a San Francisco family: 2 wds. |
| 49% | ROSEANNEBARR | 12 | Title star of a 1990s sitcom who was the honoree of a 2012 Comedy Central roast: 2 wds. |
| 47% | ROSEANNEBARR | 12 | 1990s sitcom star who was the subject of a Comedy Central Roast in 2012: 2 wds. |
| 46% | DREWCAREY | 9 | Comedian and game show host who's maintained a weight loss of over 100 pounds since 2010: 2 wds. |
| 44% | BENSTILLER | 10 | Host of a 1990s sketch comedy show who starred in and wrote both "Zoolander" movies (2 wds.) |
| 41% | THENANNY | 8 | 1990s sitcom in which a woman from Queens works for, and eventually marries, a Broadway producer: 2 wds. |
| 39% | IWON | 4 | The name of a hit 2014 single by Future and Kanye West: 2 wds. |
| 39% | HANNAHGADSBY | 12 | Australian comedian and writer who has a comedy special on Netflix titled "Nanette": 2 wds. |
| 39% | RICKYGERVAIS | 12 | English comedian and actor who has a comedy special on Netflix titled "Humanity": 2 wds. |
| 38% | SUEME | 5 | Snide challenge which was also the name of a song on "Guys and Dolls": 2 wds. |
| 38% | ROSIEODONNELL | 13 | Host of a self-titled talk show who hosted the 1999 and 2000 Grammy ceremonies: 2 wds. |
| 38% | KRISHUMPHRIES | 13 | Brooklyn Nets player and husband of 15-Across for 72 days in 2011: 2 wds. |
| 37% | COCOCHANEL | 10 | French fashion designer and namesake of the brand that was founded in 1909 and is known for its perfume No. 5: 2 wds. |
| 37% | STEPHENIEMEYER | 14 | "Twilight" author and winner of a National Merit Scholarship in 1992: 2 wds. |
| 36% | GENEHACKMAN | 11 | Winner of a Best Actor Oscar for "The French Connection" and a Best Supporting Actor Oscar for "Unforgiven": 2 wds. |
| 36% | ELLENDEGENERES | 14 | Comedian who starred in a self-titled sitcom from 1994 to 1998: 2 wds. |
| 36% | STEVEHARVEY | 11 | Comedian who starred in a self-titled sitcom from 1996 to 2002: 2 wds. |
| 36% | SAMSNEAD | 8 | Winner of a record 82 PGA Tour events, and a charter member of the World Golf Hall of Fame: 2 wds. |
| 35% | JERRYSEINFELD | 13 | Comedian who played a fictional version of himself on a sitcom about "nothing" (2 wds.) |
| 35% | INGRIDBERGMAN | 13 | Winner of a Best Actress Oscar for "Gaslight" and a Best Supporting Actress Oscar for "Murder on the Orient Express": 2 wds. |
| 35% | GEORGELOPEZ | 11 | Comedian who starred in a self-titled sitcom from 2002 to 2007, and another that started in 2016: 2 wds. |
| 35% | RACHELCARSON | 12 | "Silent Spring" writer and namesake of the international environmental award won by 32-Across in 2019 (2 wds.) |
| 35% | THENANNY | 8 | 1990s sitcom starring Fran Drescher: 2 wds. |
| 35% | NOTORIOUSRBG | 12 | Title of a book (and numerous memes) about Justice Ruth Bader Ginsburg: 2 wds. |