| 100% | SNL | 3 | Buck Henry was the first to host it five times, briefly |
| 49% | CANDICEBERGEN | 13 | Actress who was the first woman to host "Saturday Night Live," and the first woman to host five times (2 wds.) |
| 48% | TINAFEY | 7 | Actress/writer who was the first woman to be head writer of "Saturday Night Live," and the third woman to host five times (2 wds.) |
| 42% | BLAZEATRAIL | 11 | Be the first to accomplish something (and do it spectacularly!) |
| 41% | MBA | 3 | Harvard was the first to offer it (1908) |
| 40% | STATEDEPARTMENT | 15 | Thomas Jefferson was the first to lead it |
| 40% | SECRETBALLOT | 12 | Australia was the first country to implement it |
| 39% | INC | 3 | Business magazine that, in 1981, was the first to feature Steve Jobs on its cover |
| 38% | ERIECANAL | 9 | The Seneca Chief was the first to travel its full length |
| 38% | CLARINET | 8 | Mozart was the first major composer to write specifically for it |
| 38% | TELEPHONE | 9 | Alexander Graham Bell was the first to patent it |
| 38% | MILE | 4 | Roger Bannister was the first to run it in under four minutes |
| 38% | ETHEL | 5 | Waters who was the first Black American to host a national television show |
| 38% | YORK | 4 | New ___, state where Buffalo was the first city to host a Turkey Trot |
| 38% | ERNANI | 6 | Verdi work that was the first opera to be recorded in its entirety |
| 38% | PGA | 3 | Babe Zaharias was the first woman to compete on its tour, in brief |
| 38% | IMAC | 4 | Apple device that was the first to employ its "i" prefix |
| 37% | SAMESEXMARRIAGE | 15 | The Netherlands was the first country to legalize it |
| 37% | ALI | 3 | Boxer Muhammad who was the first heavyweight to win the championship belt three times |
| 37% | NAOMAMPBELL | 11 | *Woman who was the first Black model to appear on the cover of Time |
| 37% | RADIO | 5 | It was used to play music for the first time in 1906 |
| 37% | STTERESA | 8 | First woman to be named Doctor of the Church, briefly |
| 37% | BRAEKHUS | 8 | Cecilia ___, Norwegian boxer who was the first-ever boxer to hold five world titles simultaneously |
| 37% | ONEPIN | 6 | It's often the first to be knocked over |
| 36% | COIN | 4 | Be the first to use |
| 36% | COIN | 4 | Be the first to say |
| 36% | WIN | 3 | Be the first to finish |
| 36% | DISCOVER | 8 | Be the first to find |
| 36% | MALAYSIA | 8 | Kuala Lumpur's country that was the first Asian country to host the Commonwealth Games in 1998 |
| 36% | NORTHWESTPASSAGE | 16 | The SS Manhattan was the first commercial ship to cross it |