| 100% | PALMSPRINGS | 11 | California city that, in 2018, became the first U.S. city to have an all-L.G.B.T. city council |
| 43% | RADIO | 5 | In 1922, Warren G. Harding became the first U.S. president to be broadcast over this |
| 39% | WARRENGHARDING | 14 | U.S. president who, in 1922, became the first president to have his voice transmitted on the radio (3 wds.) |
| 39% | SANLUISOBISPO | 13 | California city that’s home to the first motel |
| 36% | KUDZU | 5 | Plant that has become invasive in much of the Eastern U.S. |
| 36% | ODESSA | 6 | City that was home to the first car in Russia |
| 35% | OMAR | 4 | Ilhan ___, who became the first Somali-American elected to the U.S. Congress (November, 2018) |
| 35% | MIAMI | 5 | City where Kim Ng became M.L.B.’s first female G.M., in 2020 |
| 34% | ALABAMA | 7 | Montgomery's state that was the first US state to recognize Christmas as a holiday in 1836 |
| 34% | OBERLIN | 7 | Ohio college that was the first in the U.S. to admit women |
| 34% | MESA | 4 | U.S. city that becomes another U.S. city if you move the last letter to the front |
| 34% | AIR | 3 | Song that becomes the musical it's in if you add an "H" to the front |
| 34% | AMYMCGRATH | 10 | First woman to fly an F/A-18 in combat for the U.S. Marine Corps |
| 33% | JAMESMADISON | 12 | U.S. president who was the first to have served in the House of Representatives, the first to have an inaugural ball, and the first to wear long pants instead of knee breeches (2 wds.) |
| 33% | OBERLIN | 7 | Ohio college that was the first in the U.S. to award degrees to women |
| 33% | NAPLES | 6 | City in Italy that had the first-known pizzeria |
| 33% | BLACKPANTHER | 12 | Marvel's 2018 superhero film that became the first film since "Avatar" to top the box office for five consecutive weekends: 2 wds. |
| 33% | STLOUIS | 7 | First U.S. city to host the Olympics |
| 33% | SPICEGIRLS | 10 | First British group since the Beatles to have two albums in the U.S. top 10 at the same time |
| 32% | STLOUIS | 7 | First U.S. city to host the Olympic Games |
| 32% | STL | 3 | First U.S. city to host the Olympics (Abbr.) |
| 32% | STL | 3 | First U.S. city to host the Olympic Games |
| 32% | SALT | 4 | ___ Lake City, US city that was host to the Winter Olympics held in 2002 |
| 32% | SANJOSE | 7 | California city that's home to the NHL's Sharks: 2 wds. |
| 32% | AHA | 3 | First Norwegian band to have a #1 hit in the US: Hyph. |
| 32% | IKEA | 4 | Company that was the first in the U.S. to air a TV ad with a gay couple (1994) |
| 32% | GIRL | 4 | ___ Named Tom, musical group that became the first trio to win "The Voice" in 2021 |
| 32% | REFORM | 6 | — Club, association founded in Pall Mall in 1836 that in 1981 became the first of the old London clubs to admit ladies as members |
| 32% | GALWAY | 6 | "___ Girl," song by English singer Ed Sheeran which has the name of an Irish city in its title that is home to Eyre Square |
| 32% | BASRA | 5 | Mideast city that is the capital of the world in H. G. Wells's "The Shape of Things to Come" |