| 100% | DELMONTE | 8 | Canned food company based in San Francisco: 2 wds. |
| 54% | UBER | 4 | Popular ridesharing company based in San Francisco |
| 52% | ILEFT | 5 | "___ My Heart in San Francisco": 2 wds. |
| 50% | ILEFT | 5 | Tony Bennett's "___ My Heart in San Francisco": 2 wds. |
| 48% | SUDDENLYSUSAN | 13 | 1996-2000 sitcom starring 15-Across as a magazine writer in San Francisco: 2 wds. |
| 45% | TONYBENNETT | 11 | "I Left My Heart in San Francisco" singer who's an accomplished painter: 2 wds. |
| 43% | TONYBENNETT | 11 | 2018 AP Coach of the Year who shares his name with the singer of "I Left My Heart in San Francisco": 2 wds. |
| 43% | ILEFT | 5 | "___ My Heart in San Francisco" (Tony Bennett classic) (2 wds.) |
| 43% | YOPLAIT | 7 | International food company based in Paris |
| 43% | STEVEMCQUEEN | 12 | "Bullitt" actor who played a San Francisco fire chief in "The Towering Inferno": 2 wds. |
| 42% | EBAY | 4 | *Fortune 500 company based in San Jose, Calif. |
| 41% | ALEXSMITH | 9 | Chiefs quarterback who was picked #1 overall by the San Francisco 49ers in the 2005 NFL draft: 2 wds. |
| 41% | BAYAREA | 7 | Region around San Francisco: 2 wds. |
| 40% | BAYAREA | 7 | Northern California region that includes San Francisco: 2 wds. |
| 40% | PAULADEEN | 9 | Food Network star based in Georgia who has no formal culinary training: 2 wds. |
| 40% | NIGELLALAWSON | 13 | Food Network star based in England who has no formal culinary training: 2 wds. |
| 40% | UBER | 4 | Rideshare company headquartered in San Francisco |
| 40% | UBER | 4 | Transportation company headquartered in San Francisco |
| 40% | CLINTEASTWOOD | 13 | San Francisco-born actor who played Harry Callahan in the "Dirty Harry" films (2 wds.) |
| 40% | INAGARTEN | 9 | Food Network star based in New York who has no formal culinary training: 2 wds. |
| 39% | TONYBENNETT | 11 | "I Left My Heart in San Francisco" singer honored with the 2017 Gershwin Prize for Popular Song (2 wds.) |
| 38% | SONY | 4 | ___ Interactive Entertainment, gaming company based in San Mateo which is famous for the PlayStation consoles |
| 38% | GEORGEKITTLE | 12 | San Francisco 49ers tight end featured on "Receiver": 2 wds. |
| 37% | NASHBRIDGES | 11 | Police procedural set in San Francisco starring 13-Across and 25-Across that began its six-year run in 1996 (2 wds.) |
| 36% | CABLECAR | 8 | San Francisco vehicle (2 wds.) |
| 35% | LIEVSCHREIBER | 13 | San Francisco-born actor who plays Ray Donovan in "Ray Donovan" (2 wds.) |
| 35% | BAYAREA | 7 | San Francisco and environs (2 wds.) |
| 35% | FULLERHOUSE | 11 | Netflix reboot of a 1990s sitcom about a San Francisco family: 2 wds. |
| 34% | BILLWALSH | 9 | American football coach who won three Super Bowls for San Francisco 49ers: 2 wds. |
| 34% | SANJOSESHARKS | 13 | NHL team based in California that has never won the Stanley Cup: 2 wds. |