| 100% | HERSCHEL | 8 | Caroline ___, German astronomer who was the first paid female scientist |
| 58% | BESSEL | 6 | German astronomer who was the first to measure the distance to a star |
| 53% | MARIA | 5 | ___ Mitchell, astronomer who was the first female professor of astronomy and the first American to discover a comet |
| 52% | MARIECURIE | 10 | Scientist who was the first female professor at the University of Paris: 2 wds. |
| 47% | RENO | 4 | Janet who was the first female attorney general |
| 47% | RENO | 4 | Janet who was the first female US attorney general |
| 47% | INDIRA | 6 | Gandhi who was the first female PM of India |
| 47% | INDIRA | 6 | Gandhi who was the first female PM in India |
| 46% | GALILEO | 7 | Astronomer who was the first to discover that the Milky Way was made up of stars |
| 46% | ULRIC | 5 | German prelate who was the first person to be canonized, A.D. 993 |
| 46% | PELOSI | 6 | Congresswoman Nancy who was the first female Speaker of the House |
| 46% | RICE | 4 | Condoleezza who was the first female African-American secretary of state |
| 45% | AMELIA | 6 | Earhart who was the first female aviator to fly solo across the Atlantic |
| 45% | CANDICEBERGEN | 13 | Actress who was the first female host of "Saturday Night Live": 2 wds. |
| 45% | CLINTON | 7 | Hillary ___, politician and icon who was the first female senator from New York |
| 44% | BARBARA | 7 | ___ A. Williams, American radio astronomer who was the first African-American woman to gain a PhD in Astronomy |
| 44% | CHAO | 4 | Elaine ___, Bush's labor secretary who was the first female Asian-American cabinet member |
| 44% | NANCYPELOSI | 11 | Democratic congresswoman from California who was the first female Speaker of the House: 2 wds. |
| 44% | CANDICEBERGEN | 13 | "Murphy Brown" star who was the first female host of "Saturday Night Live": 2 wds. |
| 44% | RENO | 4 | Janet who was the U.S.’s first female Attorney General |
| 43% | AMELIA | 6 | American aviator ___ Earhart who was the first female aviator to fly solo across the Atlantic Ocean |
| 43% | MOMSMABLEY | 10 | Trailblazing African American who was the first female comedian to perform at the Apollo Theater: 2 wds. |
| 43% | DEBBIE | 6 | ___ Armstrong, former alpine skier who was the first female American skier to win an Olympic gold medal |
| 42% | PATSY | 5 | Cline who was the first solo female artist elected to the Country Music Hall of Fame |
| 42% | ANNPRESTON | 10 | American physician and activist who was the first female dean of a medical school in the world: 2 wds. |
| 41% | PATSYCLINE | 10 | American singer (birthday today) who was the first female solo artist inducted to the Country Music Hall of Fame: 2 wds. |
| 40% | ANNEASKEW | 9 | Protestant martyr who was also one of the first-known English-language female poets |
| 39% | DOLLY | 5 | Sheep who was the first cloned mammal |
| 39% | LAIKA | 5 | Dog who was the first animal in space |
| 39% | ELMO | 4 | Lincoln who was the first screen adult Tarzan |