| 100% | SLADE | 5 | Carter ___, character that debuted in Ghost Rider number 1 as the first to wear the mask |
| 36% | THEFLINTSTONES | 14 | Television series set in Bedrock that debuted in 1960 as the first animated series to run in prime time (2 wds.) |
| 31% | THENETHERLANDS | 14 | European country that legalized same-sex marriage on April 1, 2001, the first country in the world to do so (2 wds.) |
| 31% | ALABAMA | 7 | Montgomery's state that was the first US state to recognize Christmas as a holiday in 1836 |
| 30% | SOLE | 4 | Shoe part that's usually the first to wear out |
| 30% | HAND | 4 | "I Want to Hold Your ___," 1963 song by The Beatles which was their first number 1 hit in America |
| 29% | SKYFALL | 7 | 2012 Adele hit that was the first James Bond theme to debut in the top 10 on Billboard's Hot 100 |
| 29% | RHODA | 5 | First TV show to debut at #1 in the Nielsen ratings |
| 29% | INCISORS | 8 | Teeth that are typically the first to grow in |
| 28% | REFORM | 6 | — Club, association founded in Pall Mall in 1836 that in 1981 became the first of the old London clubs to admit ladies as members |
| 28% | CEDILLA | 7 | Character such as that placed under the c in French name Francois that softens the sound from that of k to s |
| 28% | ERIE | 4 | Great Lake that's usually the first to freeze in winter |
| 28% | BADROMANCE | 10 | 2009 song by Lady Gaga that made her the first female in British chart history to have three number-one singles in one year: 2 wds. |
| 28% | HAYES | 5 | First president to have a phone in the White House—its number was "1" (1877) |
| 28% | SHALOMMEIRTOWER | 15 | Tel Aviv skyscraper that was the first to be built in the Mideast |
| 28% | PALM | 4 | Co. that was the first to successfully market a PDA worldwide in 1997 |
| 27% | TMZ | 3 | Hollywood website that was the first to report Michael Jackson's death in 2009 |
| 27% | ODESSA | 6 | City that was home to the first car in Russia |
| 27% | SLIMSHADY | 9 | "The Real ___," Eminem's first song to reach number one in the U.K, with a video that parodied several real-life celebrities: 2 wds. |
| 27% | TESLA | 5 | Car company that debuted its first vehicle, the Roadster, in 2008 |
| 27% | PSY | 3 | Singer in the first YouTube video to surpass 1 billion views |
| 27% | ALA | 3 | State, in short, which had as its first permanent capital the community of Cahaba, now a ghost town |
| 26% | MARLINS | 7 | Florida squad that was the first to win two World Series titles as a wild-card team |
| 26% | LEASALONGA | 10 | As Kim in “Miss Saigon,” she became the first Asian woman to win a Tony |
| 26% | INC | 3 | Business magazine that, in 1981, was the first to feature Steve Jobs on its cover |
| 26% | HIJAB | 5 | Halima Aden became the first Sports Illustrated model to wear one in 2019 |
| 26% | OBERLIN | 7 | Ohio college that was the first in the U.S. to admit women |
| 26% | ERNANI | 6 | Verdi work that was the first opera to be recorded in its entirety |
| 26% | METS | 4 | M.L.B. team that was the first to trade a player for himself (Harry Chiti in 1962) |
| 26% | GOOFY | 5 | Character that debuted in Mickey's Revue |