| 100% | HELLOKITTY | 10 | Cartoon character with a red hair bow who was appointed a children's ambassador by UNICEF (2 wds.) |
| 49% | JUDYJETSON | 10 | Cartoon character with a black hair bow who attends Orbit High School (2 wds.) |
| 44% | PRINCESSMERIDA | 14 | Disney cartoon character with red hair whose best friend is a horse named Angus (2 wds.) |
| 43% | MAGGIESIMPSON | 13 | Cartoon character with a blue hair bow whose long-running series debuted in 1989 (2 wds.) |
| 40% | CHUCKIEFINSTER | 14 | Nickelodeon cartoon character with red hair whose best friend is Tommy Pickles (2 wds.) |
| 38% | VERUCASALT | 10 | Child in Roald Dahl's "Charlie and the Chocolate Factory" who is thrown down a garbage chute by squirrels: 2 wds. |
| 37% | ANGIEHARMON | 11 | "Rizzoli & Isles" actress who was named a UNICEF Ambassador in 2013: 2 wds. |
| 37% | NEDFLANDERS | 11 | "The Simpsons" character who is portrayed as a good neighbour with his wife Maude and two children, Rod and Todd: 2 wds. |
| 37% | JESSEPINKMAN | 12 | Character played by Aaron Paul in "Breaking Bad", who was a crystal meth dealer and worked with the character played by 30-Across: 2 wds. |
| 37% | CHARLOTTESWEB | 13 | Children's classic by 50-Across with the line, "It is not often that someone comes along who is a true friend and a good writer" (2 wds.) |
| 37% | SELENAGOMEZ | 11 | "Wizards of Waverly Place" actress who was named a UNICEF Ambassador in 2009: 2 wds. |
| 36% | MEGANTHEE | 9 | With 43-Across, "Savage" rapper who was named a Revlon Global Brand Ambassador in 2020: 2 wds. |
| 36% | GEORGE | 6 | With 35-Across, Hanna-Barbera cartoon character with red hair whose best friend is a supercomputer named R.U.D.I. |
| 35% | COSMOKRAMER | 11 | Character played by Michael Richards in "Seinfeld", who is 32-Across's neighbor and is often called a "hipster doofus": 2 wds. |
| 35% | ORLANDOBLOOM | 12 | "Pirates of the Caribbean" actor who has been a UN Goodwill Ambassador for children: 2 wds. |
| 35% | FREDANDREWS | 11 | A "Riverdale" character who is the father of 31a, played by actor Luke Perry: 2 wds |
| 35% | HELLOKITTY | 10 | Cartoon character with a red bow on her left ear |
| 35% | NIGHTSCHOOL | 11 | 2016 novel by Lee Child in which Jack Reacher joins a mission to find a soldier who's cut a deal with a terrorist: 2 wds. |
| 35% | DWIGHTSCHRUTE | 13 | A character from "The Office" played by Rainn Wilson, who is the nemesis and eventual friend of 42a: 2 wds |
| 34% | RYANHOWARD | 10 | A character from "The Office" played by B.J. Novak, who has an on-again off-again relationship with Mindy Kaling's character: 2 wds |
| 33% | STUARTLITTLE | 12 | Children's novel by E.B. White featuring a boy who is two inches tall and looks like a mouse (2 wds.) |
| 33% | GUSTAVOFRING | 12 | Character played by Giancarlo Esposito in "Breaking Bad", who owns Los Pollos Hermanos, besides being a prominent meth distributor: 2 wds. |
| 33% | KRUSTY | 6 | With 21-Across, "The Simpsons" character who is a children's TV host |
| 33% | FLAT | 4 | Like a cartoon character who's been squished by a steamroller |
| 33% | ALICIAKEYS | 10 | American musician who co-founded and is the Global Ambassador of the nonprofit organization "Keep a Child Alive": 2 wds. |
| 33% | GRACEBYERS | 10 | "Empire" actress who authored a children's book called "I Am Enough": 2 wds. |
| 32% | GUIDOSARDUCCI | 13 | Don Novello's early "SNL" character who was a rock critic for "L'Osservatore Romano": 2 wds. |
| 32% | ALYSSA | 6 | With 30-Across, "Mistresses" actress who was named a UNICEF Ambassador in 2003 |
| 32% | TOMMYGUNN | 9 | Rocky's opponent in "Rocky V," played by real-life boxer Morrison (who shares a first name with his character): 2 wds. |
| 32% | FINNHUDSON | 10 | "Glee" character who was portrayed by 29-Across: 2 wds. |