| 100% | DAFFY | 5 | Cartoon duck who first appeared in the 1937 short "Porky's Duck Hunt" |
| 57% | DAFFYDUCK | 9 | Character first voiced by Mel Blanc in 1937 cartoon Porky's Duck Hunt |
| 50% | ABE | 3 | Animated character who first appeared in the Simpsons short "Grandpa and the Kids" |
| 49% | ABE | 3 | "Simpsons" character who first appeared in the cartoon "Grampa and the Kids" |
| 46% | TWEETYBIRD | 10 | Cartoon canary who first appeared in 1942's A Tale of Two Kitties |
| 43% | KRYPTO | 6 | ___ the Superdog, Superman's pet dog from DC Comics who first appeared in 1955 |
| 42% | GOOFY | 5 | Walt Disney character originally called Dippy Dawg who first appeared in 1932 animated cartoon Mickey's Revue |
| 42% | APU | 3 | Shopkeeper who first appears in the "Simpsons" episode "The Telltale Head" |
| 42% | BILLY | 5 | Speedy British comic character who first appeared in The Beano in 1964 |
| 41% | YOSEMITESAM | 11 | He first appeared in the cartoon "Hare Trigger" |
| 41% | NANCYDREW | 9 | Character who first appeared in "The Secret of the Old Clock" |
| 41% | XENA | 4 | Character who first appeared in "Hercules: The Legendary Journeys" |
| 41% | ACE | 3 | ___ the Bat-Hound, Batman's pet dog from DC Comics who first appeared in 1955 |
| 41% | ELMO | 4 | Red Muppet who first appeared in the "Sesame Street" song "We Are All Monsters" |
| 41% | GEORGESMILEY | 12 | Fictional spy who first appeared in "Call for the Dead" |
| 41% | ODIE | 4 | Dog who first appeared on the comic pages in 1978 |
| 40% | CHAN | 4 | Charlie —, detective creation of Earl Biggers who first appeared in The House Without a Key |
| 40% | FLASH | 5 | The —, comic book character, alter ego Jay Garrick, who first appeared in 1940 |
| 40% | DUPIN | 5 | C Auguste —, detective creation of Edgar Allan Poe who first appeared in 1841’s The Murders in the Rue Morgue |
| 40% | DUPIN | 5 | C Auguste —, detective creation of Edgar Allan Poe who first appeared in 1841's The Murders in the Rue Morgue |
| 39% | DANDY | 5 | The —, British comic featuring Korky the Cat that first appeared in 1937 |
| 39% | PADME | 5 | Queen who first appears in “The Phantom Menace” |
| 38% | YODA | 4 | Alien who first appears in "The Empire Strikes Back" |
| 38% | HUCKLEBERRY | 11 | ___ Finn, a fictional character who first appeared in 51a and is a friend of the protagonist |
| 38% | OONA | 4 | Actress Chaplin who appeared in the first season of "Game of Thrones" |
| 38% | THEEXCHANGE | 11 | 2023 novel by 41-Across that features lawyer Mitch McDeere, who first appeared in the 1991 novel "The Firm" (2 wds.) |
| 38% | DOCSAVAGE | 9 | Fictional character created by Lester Dent who first appeared in 1933 pulp novel The Man of Bronze |
| 38% | CAMPION | 7 | Albert —, detective creation of Margery Allingham who first appeared in 1929 novel The Crime At Black Dudley |