| 100% | EISNER | 6 | Cartoonist Will who popularized the term "graphic novel" |
| 60% | ALCAPP | 6 | Cartoonist who popularized the term "double whammy" |
| 51% | TYRABANKS | 9 | Model who popularized the term "smizing" |
| 50% | ENO | 3 | Brian ___, songwriter who popularized the term "generative music" |
| 48% | NAST | 4 | Cartoonist Thomas who popularized the Republican elephant and Democratic donkey |
| 47% | SPACESHIPEARTH | 14 | Amusement park attraction inspired by Buckminster Fuller, who popularized the term "geodesic dome" |
| 47% | DREWPEARSON | 11 | Wide receiver who popularized the term "Hail Mary pass" in a 1975 playoff game who is a member of the Pro Football Hall of Fame's Class of 2021 (2 wds.) |
| 45% | ALISONBECHDEL | 13 | Cartoonist who wrote and illustrated the graphic memoir "Are You My Mother?" (2 wds.) |
| 45% | POPE | 4 | Writer who popularized the saying "To err is human, to forgive divine" |
| 45% | POPMOMAND | 9 | Cartoonist who popularized the phrase "keeping up with the Joneses" |
| 45% | NAST | 4 | Cartoonist who popularized the Republican elephant and the Democratic donkey |
| 41% | JEN | 3 | Cartoonist Sorensen who was the first woman to win the Herblock Prize |
| 41% | AMES | 4 | Harry of the novel "The Man Who Cried I Am" |
| 40% | MAUS | 4 | Graphic novel by Art Spiegelman that depicts an interview with his father who is a Holocaust survivor |
| 40% | BIL | 3 | Cartoonist Keane who dropped the second “L” from his first name “just to be different” |
| 40% | MUSE | 4 | Term for one of the Greek goddesses who were an inspiration for creative people |
| 39% | IRENE | 5 | Adler who is the protagonist of the novel “Good Night, Mr. Holmes” |
| 39% | PENNYWISE | 9 | Evil clown who is the main character in Stephen King's novel "It" |
| 39% | NERO | 4 | Detective Wolfe who was the subject of 33 mystery novels by Rex Stout |
| 38% | ALCAPP | 6 | Cartoonist whom John Steinbeck said "may very possibly be the best writer in the world today" |
| 38% | QUANT | 5 | Designer who popularized the miniskirt |
| 38% | LEAR | 4 | Edward who popularized the limerick |
| 38% | BORAT | 5 | Character who popularized the "mankini" |
| 38% | MARIOPUZO | 9 | Author who wrote the novel 15-Across was based on: 2 wds. |
| 38% | DESIARNAZ | 9 | Bandleader who popularized the conga line |
| 38% | GOETHE | 6 | Author who popularized the demon Mephistopheles |
| 38% | HEMINGWAY | 9 | Ernest ___, American novelist who is famous for his novel "The Old Man and the Sea" |
| 38% | BILL | 4 | "___ Denbrough," fictional character who is the main protagonist of Stephen King's 1986 novel "It" |
| 37% | DWIGGINS | 8 | William Addison __, coined the term graphic design |
| 37% | DRAKE | 5 | Canadian rapper who popularized the acronym "YOLO" |