| 100% | POISONDART | 10 | Cause of death in Sir Arthur Conan Doyle’s “The Sign of the Four” |
| 54% | POISOND | 7 | Cause of death in the Sherlock Holmes novel "The Sign of the Four" |
| 46% | FOUR | 4 | "The Sign of the ___," Sherlock Holmes novel by Arthur Conan Doyle |
| 43% | SIGN | 4 | "The ___ of the Four" (Arthur Conan Doyle novel) |
| 43% | ASTUDYIN | 8 | & 16D First of four Sherlock Holmes novels by Arthur Conan Doyle, published in book form in 1888 |
| 42% | IRREGULARS | 10 | "The ___," 2021 period drama series based on the works of Sir Arthur Conan Doyle |
| 42% | POLE | 4 | "The Captain of the ___-Star," short story by Arthur Conan Doyle that was published in the Temple Bar |
| 40% | ALLOSAURUS | 10 | Terror in Arthur Conan Doyle's "The Lost World" |
| 40% | ADLER | 5 | Irene in a short story by Sir Arthur Conan Doyle |
| 39% | SHERLOCK | 8 | Sir Arthur Conan Doyle's fictional detective |
| 39% | SIR | 3 | ___ Arthur Conan Doyle (title for the creator of Sherlock Holmes) |
| 38% | BELL | 4 | Joseph ___, surgeon whom Arthur Conan Doyle cites as inspiration for the character of Sherlock Holmes |
| 38% | SIR | 3 | Arthur Conan Doyle's title of respect |
| 37% | MORIARTY | 8 | Professor James —, archenemy of Sherlock Holmes in tales by Arthur Conan Doyle |
| 37% | BASKERVILLES | 12 | "The Hound of the ___," Sherlock Holmes novel by Arthur Conan Doyle |
| 37% | MORIARTY | 8 | Professor James —, arch-enemy of Sherlock Holmes in stories by Arthur Conan Doyle |
| 37% | VALLEY | 6 | "The Mystery of the Sasassa ___," first published work by Arthur Conan Doyle |
| 36% | BAND | 4 | "The Adventure of the Speckled ___," Sherlock Holmes short story by Arthur Conan Doyle |
| 36% | ELEMENTARY | 10 | CBS detective series based on the characters of Arthur Conan Doyle |
| 36% | BAKERSTREET | 11 | & 1A Group of street urchins who aid Sherlock Holmes in various stories by Arthur Conan Doyle |
| 36% | DOYLE | 5 | "The Sign of the Four" author |
| 35% | NERO | 4 | Charles Laughton's role in "The Sign of the Cross" |
| 35% | ALBATROSS | 9 | Bird whose death causes a curse in "The Rime of the Ancient Mariner" |
| 35% | FINAL | 5 | & 16A The —, Sherlock Holmes story by Arthur Conan Doyle first published in the Strand Magazine in December 1893 |
| 35% | ARTHUR | 6 | Sir ___ Conan Doyle, creator of "Sherlock Holmes" who went to the University of Edinburgh Medical School |
| 35% | POISON | 6 | Cause of death in some cozy mysteries |
| 35% | LOST | 4 | "The ___ World," first book featuring the character of Professor Challenger created by Arthur Conan Doyle |
| 34% | HOLMES | 6 | Sherlock ___, Sir Arthur Conan Doyle's brilliant detective who is never seen without his signature deerstalker hat |
| 34% | CYANIDE | 7 | Cause of death in many a murder mystery |
| 34% | IRENEADLER | 10 | Fictional opera singer/actress who outsmarts Sherlock Holmes in the Arthur Conan Doyle story "A Scandal in Bohemia" (2 wds.) |