| 100% | ARSON | 5 | Cause of something going up? |
| 75% | ARSON | 5 | Cause of everything going up? |
| 58% | REASONS | 7 | Causes of something |
| 51% | TIE | 3 | Cause of a game going into overtime |
| 50% | PHOBIA | 6 | Powerful fear of something, causes panic |
| 50% | PHOBIA | 6 | Irrational fear of something, causes panic |
| 49% | EFFECT | 6 | A result of something else; cause and __ |
| 47% | CONFUSES | 8 | Mixes something up, causes bewilderment |
| 47% | CLIMB | 5 | Go up, like someone trying to reach the top of a mountain |
| 46% | SMOKEALARM | 10 | Unpleasant cause of being woken up |
| 46% | APNEA | 5 | Cause of a wake-up |
| 46% | ADWARE | 6 | Cause of pop-ups |
| 46% | PAIL | 4 | "Jack & Jill went up the hill to fetch a ___ of water..." |
| 45% | STEPS | 5 | There are 393 in the staircase going up the Statue of Liberty |
| 45% | PAIL | 4 | "Jack and Jill went up the hill to fetch a ___ of water" |
| 45% | BADPENNY | 8 | Something unpleasant that always turns up, so the saying goes |
| 44% | GOOGLE | 6 | Where many go to look something up online |
| 44% | MERGE | 5 | Cause of a traffic tie-up |
| 44% | RAGWEED | 7 | Cause of some allergy flare-ups |
| 44% | SASH | 4 | Something the narrator of "A Visit From St. Nicholas" threw up |
| 44% | INFANT | 6 | Something that often shows up at the end of Labor Day |
| 43% | HEADCOLD | 8 | Cause of a stuffed-up nose |
| 43% | BEATADEADHORSE | 14 | Not let go of something |
| 43% | FEAR | 4 | Something that koumpounophobia might cause every time you button up your jacket |
| 43% | URIC | 4 | Build up of this acid around joints can cause gout |
| 43% | STAIRCASE | 9 | Something that goes up and down but doesn't move |
| 42% | SELL | 4 | Let go of something, in exchange of money |
| 42% | CONJURE | 7 | "___ something up," to call upon something through the use of a spell |
| 41% | TBAR | 4 | One means of going up a hill |
| 40% | EGG | 3 | Something that's gone bad if it floats when placed in a bowl of water |