| 100% | CLARICE | 7 | CBS crime series based on "The Silence of the Lambs" starring 44-Across as the title FBI agent |
| 40% | SPY | 3 | "The ___," Netflix series based on the life of a Mossad agent directed by Gideon Raff and starring Sacha Baron Cohen |
| 39% | ELEMENTARY | 10 | CBS detective series based on the characters of Arthur Conan Doyle |
| 34% | THENIGHTAGENT | 13 | Netflix action thriller series starring 18-Across and Luciane Buchanan based on the novel of the same name by 40-Across (3 wds.) |
| 33% | WONDER | 6 | "___ Woman," 1976 series starring Lynda Carter based on the Greek lore of the Amazons |
| 33% | MOTH | 4 | Critter on "The Silence of the Lambs" poster |
| 33% | RICHIERICH | 10 | A 1994 film based on the comics of the same name, starring Macaulay Culkin (birthday today) as the world's wealthiest kid: 2 wds. |
| 33% | CLARICE | 7 | FBI agent Starling played by Jodie Foster in "The Silence of the Lambs" |
| 33% | SWEETBITTER | 11 | American drama TV series starring Ella Purnell which is based on a novel of the same name by Stephanie Danler |
| 33% | INTOTHEWILD | 11 | 2007 American biographical survival film based on the travels of Christopher McCandless across North America, starring Emile Hirsch: 3 wds. |
| 33% | BIG | 3 | With 60-Across, TV crime series based on the novel "The Highway" by C.J. Box |
| 32% | FBI | 3 | Crime-fighting agency in "The Silence of the Lambs": Abbr. |
| 32% | ACE | 3 | "___ Ventura: Pet Detective," an animated series based on the film of the same name |
| 32% | THEALIENIST | 11 | American period drama TV series starring Dakota Fanning which is based on a novel of the same name by Caleb Carr: 2 wds. |
| 32% | VIKINGS | 7 | Historical drama series based on the journey of Ragnar Lothbrok |
| 32% | WARRIOR | 7 | *Martial arts series based on the writings of Bruce Lee |
| 31% | REBECCABREEDS | 13 | "Pretty Little Liars" actress who plays the title FBI agent on 34-Across (2 wds.) |
| 31% | FBI | 3 | Crime-fighting agency seen in "The Silence of the Lambs": Abbr. |
| 31% | ROBERTYOUNG | 11 | He starred as the title character on 28-Across: 2 wds. |
| 31% | NEEDFORSPEED | 12 | 2014 action film starring Aaron Paul, based on the car racing video game series of the same name: 3 wds. |
| 31% | ALTEREDCARBON | 13 | American dystopian sci-fi TV series starring Joel Kinnaman which is based on a novel of the same name by Richard K. Morgan: 2 wds. |
| 31% | SRI | 3 | Honorific title repeated based on the status of the person being addressed |
| 31% | JOSIE | 5 | "___ and the Pussycats," 2001 live-action film starring Rachael Leigh Cook based on the comic book series of the same name |
| 31% | GEORGE | 6 | "___ of the Jungle," 1997 live-action film starring Brendan Fraser that is based on the popular animated series |
| 31% | GRAPES | 6 | "The ___ of Wrath," 1940 film starring Henry Fonda as a sharecropper, based on the eponymous John Steinbeck novel |
| 31% | IRREGULARS | 10 | "The ___," 2021 period drama series based on the works of Sir Arthur Conan Doyle |
| 31% | ANNE | 4 | "___ Boleyn," 2021 period drama series based on the life of an English Queen |
| 31% | ANNE | 4 | “___ with an E” (TV series based on the works of Lucy Maud Montgomery) |
| 31% | STREETFIGHTER | 13 | 1994 Japanese-American action film starring Jean-Claude Van Damme, based on the video game series of the same name: 2 wds. |
| 31% | MOTH | 4 | Flying insect on classic "The Silence of the Lambs" movie posters |