| 100% | ONEDAYATATIME | 13 | CBS sitcom about a divorced mother raising two teenaged daughters that ran from 1975 to 1984: 5 wds. |
| 30% | MALIBUCOUNTRY | 13 | Sitcom about a divorced mom who relocates to California: 2 wds. |
| 29% | THEUNICORN | 10 | New CBS sitcom about a widower trying to date again: 2 wds. |
| 29% | BRADYBUNCH | 10 | "The ___," ABC sitcom about a large blended family with six children that ran from 1969 - 1974: 2 wds. |
| 27% | ONEDAYATATIME | 13 | Norman Lear sitcom about a single mom and her daughters, revived in 2017: 5 wds. |
| 27% | SCHITTSCREEK | 12 | Pop TV sitcom about a formerly rich family forced to live in a run-down motel: 2 wds. |
| 26% | THE | 3 | "All in ___ Family," CBS sitcom about the life of a working-class father and his family that ran from 1971 - 1979 |
| 26% | BECKER | 6 | CBS sitcom about a cantankerous doctor that starred Ted Danson |
| 25% | OLIVEAGAIN | 10 | Elizabeth Strout novel that features a story about the mother from 16-Across (2 wds.) |
| 24% | POLICEACADEMY | 13 | 1984 comedy starring Steve Guttenberg and Kim Cattrall that led to six sequels, a sitcom, and an animated series (2 wds.) |
| 24% | THETERMINATOR | 13 | 1984 movie about a cyborg from the future that launched a franchise including a 2024 Netflix anime series: 2 wds. |
| 24% | ONELESS | 7 | "That's ___ thing to worry about" (words from a "Hamilton" song): 2 wds. |
| 23% | ISWRONG | 7 | Part two of six of a quote from the TV show "Gilmore Girls," that any dessert-lover can relate to?: 2 wds. |
| 23% | CSI | 3 | CBS procedural drama that ran from 2000 to 2015 |
| 23% | CSI | 3 | CBS crime drama that ran from 2000 to 2015 |
| 23% | BLESSTHISMESS | 13 | 2019 sitcom about a city couple who relocate to a Nebraska farm: 3 wds. |
| 23% | FIRECOUNTRY | 11 | CBS drama about a prison inmate who volunteers to fight blazes: 2 wds. |
| 23% | GUNSMOKE | 8 | Western TV series that ran from 1955 to 1975 |
| 23% | HALFMEN | 7 | "Two and a ___," sitcom created by Chuck Lorre and Lee Aronsohn that aired on CBS: 2 wds. |
| 22% | FREAKYFRIDAY | 12 | Fantasy-comedy film about a mother and daughter who swap bodies (2 wds.) |
| 22% | THEODD | 6 | With 30-Across, '70s sitcom about two divorced men sharing an apartment: 2 wds. |
| 22% | LEAVINGTIME | 11 | 2014 novel by 45-Across about a daughter investigating her mother's disappearance (2 wds.) |
| 21% | AMYANDISABELLE | 14 | Elizabeth Strout novel set in the fictional town of Shirley Falls about a mother and daughter (3 wds.) |
| 21% | FREEWILLY | 9 | 1993 film about a boy who tries to rescue a killer whale from an unscrupulous aquarium: 2 wds. |
| 21% | GILMOREGIRLS | 12 | Quirky 2000-2007 drama about a mother and daughter living in Stars Hollow, Connecticut: 2 wds. |
| 21% | NIGHTCOURT | 10 | 1984-1992 sitcom about a judge who presided over the evening shift: 2 wds. |
| 21% | WILDPITCH | 9 | Errant throw from the mound that allows a base runner to advance |
| 21% | DEALOUT | 7 | Omit a player from those to whom cards are dealt: 2 wds. |
| 21% | RAMBLINGROSE | 12 | 1991 drama starring 16-Across and 39-Across that is the only film to have a mother and daughter both nominated for an Oscar for the same film (2 wds.) |
| 21% | REGRETTINGYOU | 13 | 2019 bestseller by 41-Across about a mother and daughter coping with a family tragedy (2 wds.) |