| 100% | VITOCORLEONE | 12 | Character who has the title role in 15-Across: 2 wds. |
| 65% | GINARODRIGUEZ | 13 | Actress who plays the title role on 15-Across: 2 wds. |
| 61% | TONYTODD | 8 | "Final Destination" actor who plays the title role in 16-Across: 2 wds. |
| 59% | HENRYFONDA | 10 | "On Golden Pond" actor who played the title role in 32-Across: 2 wds. |
| 58% | IRENEBEDARD | 11 | Actress who voiced the title role in "Pocahontas": 2 wds. |
| 58% | DENNISQUAID | 11 | "Flight of the Phoenix" actor who plays the title role in 16-Across: 2 wds. |
| 57% | MISSDAISY | 9 | Title character whom 15-Across chauffeured around in a 1989 film: 2 wds. |
| 56% | MICHAELKEATON | 13 | "Mr. Mom" actor who played the title role in 40-Across (2 wds.) |
| 56% | OTOOLE | 6 | Peter who played the title role in 15-/50-Across |
| 56% | JULIEANDREWS | 12 | Actress who won an Oscar for playing the title role in 39-Across: 2 wds. |
| 55% | OLIVIAMUNN | 10 | "The Predator" actress who plays the title role in "Violet": 2 wds. |
| 54% | MORRISCHESTNUT | 14 | Actor who plays the title character of 47-Across in a CBS series that premiered in January: 2 wds. |
| 54% | MIKEMYERS | 9 | "SNL" alum who played the title roles in the "Austin Powers" and "Shrek" movies: 2 wds. |
| 54% | MATTHEWRHYS | 11 | "The Americans" actor who plays the title role in HBO's "Perry Mason": 2 wds. |
| 54% | KARENFUKUHARA | 13 | "Suicide Squad" actress who voices the title character in 14-/32-Across: 2 wds. |
| 54% | JULIAROBERTS | 12 | "Pretty Woman" actress who played the title role in 2000's "Erin Brockovich": 2 wds. |
| 54% | JASONMOMOA | 10 | "Conan the Barbarian" star who plays the title role in "Aquaman": 2 wds. |
| 53% | TOMHARDY | 8 | "Inception" actor who plays the title character in "Venom": 2 wds. |
| 53% | MARGOTROBBIE | 12 | "Babylon" actress who plays the title character in "Barbie": 2 wds. |
| 53% | RACHELMCADAMS | 13 | "Doctor Strange" actress who plays the title character's mom in 33-/49-Across: 2 wds. |
| 53% | BENPLATT | 8 | "The Politician" star who plays the title role in the movie adaptation of "Dear Evan Hansen": 2 wds. |
| 53% | EZRAMILLER | 10 | Actor who plays the title character in the new movie "The Flash": 2 wds. |
| 53% | RICHARDCASTLE | 13 | Writer who was the title character in a 2009-2016 crime series: 2 wds. |
| 52% | EDDIEMURPHY | 11 | "Coming to America" actor who played the title role in 1998's "Dr. Dolittle": 2 wds. |
| 52% | MICHAELKEATON | 13 | Actor with the title role in 1988's "Beetlejuice": 2 wds. |
| 52% | PATTINSON | 9 | Robert who plays the title role in 22 Across |
| 52% | BEN | 3 | Actor Gazzara who played the title role of 15-Across in a 1975 film |
| 52% | ROD | 3 | Actor Steiger who played the title role of 15-Across in a 1959 biopic |
| 51% | GINARODRIGUEZ | 13 | Former "The Bold and the Beautiful" actress who plays the title role in 41-Across (2 wds.) |
| 51% | DIANEKEATON | 11 | "Annie Hall" actress who voiced the title character's mother in 18-Across: 2 wds. |