| 100% | ATLAS | 5 | Charles —, weightlifter who conceived the Dynamic Tension system of muscle building |
| 95% | ATLAS | 5 | Charles —, weightlifter who conceived the Dynamic Tension system of muscle-building |
| 32% | ULM | 3 | Where Einstein, who conceived the General Theory of Relativity, was himself conceived |
| 30% | TONGUE | 6 | First muscle of the digestive system |
| 30% | DARWIN | 6 | Charles who developed the theory of evolution |
| 28% | EIFFEL | 6 | Engineer who built the Statue of Liberty’s framework |
| 28% | BABBAGE | 7 | Charles —, inventor born in 1791 who built a calculator that anticipated the computer |
| 28% | ALSTON | 6 | Charles who created murals for Harlem Hospital and the American Museum of Natural History |
| 28% | PERCY | 5 | Charles ___, character who tragically left the show in season 6 of "Grey's Anatomy" |
| 28% | PUTNAM | 6 | Herbert —, American librarian who originally developed the Library of Congress Classification system |
| 28% | ABELINCOLN | 10 | Political leader who patented a system to alter the buoyancy of steamboats |
| 28% | JAMIEFOXX | 9 | Actor who played the role of Ray Charles and Yahya |
| 27% | MINGUS | 6 | Charles ___, jazz double bassist who collaborated with the likes of Louis Armstrong and Duke Ellington |
| 27% | STEVEMARTIN | 11 | Portrayer of Charles-Haden Savage in "Only Murders in the Building": 2 wds. |
| 27% | CARA | 4 | Actress Delevingne who's joined the cast of "Only Murders in the Building" |
| 27% | RICHTER | 7 | Charles —, US seismologist after whom a scale for expressing the magnitude of an earthquake is named |
| 26% | JAMES | 5 | ___ Charles, American influencer who was one of the most searched figures on the Internet in 2019 |
| 26% | STEVEMARTIN | 11 | "Dirty Rotten Scoundrels" actor who plays Charles on "Only Murders in the Building" (2 wds.) |
| 26% | ENDOCRINE | 9 | System of the glands |
| 26% | SELENAGOMEZ | 11 | "Wizards of Waverly Place" actress who plays Mabel on "Only Murders in the Building" (2 wds.) |
| 25% | DARESTO | 7 | "A man who ___ waste one hour of time has not discovered the value of life." - Charles Darwin |
| 25% | DIANASPENCER | 12 | Former kindergarten assistant who married Prince Charles to become the Princess of Wales in 1981: 2 wds. |
| 25% | GLEN | 4 | ___ and Les Charles, screenwriting duo who are known for being co-creators of the TV show "Cheers" |
| 25% | HIFI | 4 | Sound system of the '50s |
| 25% | LEET | 4 | System of modified spellings used on the internet |
| 24% | DIAPHRAGM | 9 | Wall of muscles below the ribcage |
| 24% | ELECTORAL | 9 | Of the voting system |
| 24% | OSTEOPATHY | 10 | System of healing based on the manipulation of bones |
| 24% | CARDIAC | 7 | Type of muscle used in the heart |
| 24% | DAYLIGHT | 8 | __ saving time, system of adjusting the clocks |