| 100% | CHAN | 4 | Charlie —, detective creation of Earl Biggers who first appeared in 1925 novel The House Without a Key |
| 81% | CHAN | 4 | Charlie —, detective creation of Earl Biggers who first appeared in The House Without a Key |
| 47% | CAMPION | 7 | Albert —, detective creation of Margery Allingham who first appeared in 1929 novel The Crime At Black Dudley |
| 43% | CHAN | 4 | Fictional character who first appeared in "The House Without a Key" |
| 39% | NANCYDREW | 9 | Fictional girl detective who first appeared in 1930 novel The Secret of the Old Clock by Carolyn Keene |
| 37% | PERRYMASON | 10 | Lawyer creation of Erle Stanley Gardner who first appeared in 1933 novel The Case of the Velvet Claws |
| 36% | PERRY | 5 | & 25A Lawyer creation of Erle Stanley Gardner who first appeared in 1933 novel The Case of the Velvet Claws |
| 35% | DOCSAVAGE | 9 | Fictional character created by Lester Dent who first appeared in 1933 pulp novel The Man of Bronze |
| 34% | RAISIN | 6 | Agatha —, fictional creation of M C Beaton who first appeared in a 1992 mystery novel |
| 32% | INSPECTORBUCKET | 15 | “Bleak House” character who was one of the first detectives in English fiction |
| 32% | DUPIN | 5 | C Auguste —, detective creation of Edgar Allan Poe who first appeared in 1841’s The Murders in the Rue Morgue |
| 32% | DUPIN | 5 | C Auguste —, detective creation of Edgar Allan Poe who first appeared in 1841's The Murders in the Rue Morgue |
| 32% | NANCYDREW | 9 | Character who first appeared in "The Secret of the Old Clock" |
| 31% | TWEETYBIRD | 10 | Cartoon canary who first appeared in 1942's A Tale of Two Kitties |
| 31% | NANCYDREW | 9 | Fictional young female detective who first appeared in a 1930 book credited to the pen name Carolyn Keene: 2 wds. |
| 31% | HUCKLEBERRY | 11 | ___ Finn, a fictional character who first appeared in 51a and is a friend of the protagonist |
| 31% | HARDYBOYS | 9 | Fictional young male detectives who first appeared in a 1927 book credited to the pen name Franklin W Dixon: 2 wds. |
| 29% | THOR | 4 | Superhero with a hammer who appeared in the first issue of the comic book "The Avengers" |
| 29% | CASE | 4 | Word in the title of many a detective novel |
| 28% | SEXTONBLAKE | 11 | Fictional detective who first appeared in 1893 story The Missing Millionaire by Hal Meredeth aka Harry Blyth |
| 28% | BOBBSEYTWINS | 12 | Fictional young brother-and-sister detectives who first appeared in a 1904 book credited to the pen name Laura Lee Hope: 2 wds. |
| 27% | FAE | 3 | Baby who was the first infant subject of a xenotransplant procedure in 1984 |
| 27% | DERR | 4 | Earl ___ Biggers, mystery writer of the "Charlie Chan" novels |
| 27% | TRIXIEBELDEN | 12 | Fictional young female detective who first appeared in a 1948 book by Julie Campbell Tatham: 2 wds. |
| 27% | TOBY | 4 | ___ Flenderson, HR representative who had a recurring role in the first season of "The Office" |
| 27% | APU | 3 | Shopkeeper who first appears in the "Simpsons" episode "The Telltale Head" |
| 27% | XENA | 4 | Character who first appeared in "Hercules: The Legendary Journeys" |
| 27% | VANDERVALK | 10 | Piet —, Dutch detective created by Nicholas Freeling who first appeared in 1962 novel Love in Amsterdam |