| 100% | JANEEYRE | 8 | Charlotte Brontë title character: 2 wds. |
| 66% | ORSONWELLES | 11 | Actor who directed 17-Across and played the title character: 2 wds. |
| 65% | THEMANDALORIAN | 14 | Disney+ space western on which 19-Across plays the title character: 2 wds. |
| 65% | OLIVERTWIST | 11 | Orphan title character created by Charles Dickens: 2 wds. |
| 64% | EMMANUELLEWIS | 13 | Actor who played the title character on "Webster": 2 wds. |
| 64% | WILLARNETT | 10 | Voice of the title character on 36-Across: 2 wds. |
| 63% | MISSDAISY | 9 | Title character whom 15-Across chauffeured around in a 1989 film: 2 wds. |
| 63% | TOMHARDY | 8 | "Inception" actor who plays the title character in "Venom": 2 wds. |
| 63% | ROBERTYOUNG | 11 | He starred as the title character on 28-Across: 2 wds. |
| 63% | MARGOTROBBIE | 12 | "Babylon" actress who plays the title character in "Barbie": 2 wds. |
| 62% | BEATRIXPOTTER | 13 | Author/illustrator who created the title character of 18-Across: 2 wds. |
| 62% | LINDALAVIN | 10 | Actress who played the title character on the sitcom "Alice": 2 wds. |
| 62% | JOHNNYBRAVO | 11 | Muscular title character in a 1997-2004 Cartoon Network series: 2 wds. |
| 62% | THEIDENTICALS | 13 | 2017 Elin Hilderbrand novel whose title characters are twin sisters: 2 wds. |
| 61% | EDIEFALCO | 9 | "The Sopranos" actress who played the title character on "Nurse Jackie": 2 wds. |
| 61% | SONICTHE | 8 | With 42-Across, speedy blue title character of a 2020 film: 2 wds. |
| 61% | TOMHIDDLESTON | 13 | "Kong: Skull Island" star who plays the title character on "Loki": 2 wds. |
| 60% | RICHARDCASTLE | 13 | Writer who was the title character in a 2009-2016 crime series: 2 wds. |
| 60% | STEVENUNIVERSE | 14 | Half-human, half-alien title character in a current Cartoon Network series: 2 wds. |
| 60% | KARENFUKUHARA | 13 | "Suicide Squad" actress who voices the title character in 14-/32-Across: 2 wds. |
| 60% | EZRAMILLER | 10 | Actor who plays the title character in the new movie "The Flash": 2 wds. |
| 60% | KENNETHBRANAGH | 14 | Actor who directed and played the title character in 1996's "Hamlet": 2 wds. |
| 60% | JAMESCORDEN | 11 | "The Late Late Show" host who voices the title character in 18-Across: 2 wds. |
| 60% | HONKYCAT | 8 | 1972 Elton John song where the title character is told to "get back": 2 wds. |
| 60% | DIANEKEATON | 11 | "Annie Hall" actress who voiced the title character's mother in 18-Across: 2 wds. |
| 60% | VERONICAMARS | 12 | Teen mystery drama (2004-2007) in which the title character went through adolescence: 2 wds. |
| 60% | TARONEGERTON | 12 | "Kingsman: The Golden Circle" actor who plays the title character in 16-Across: 2 wds. |
| 60% | MRSMAISEL | 9 | "Marvelous" stand-up comic and title character of an Emmy-winning Amazon series: 2 wds. |
| 60% | SAMURAIJACK | 11 | Sword-wielding title character in a 2001-2004 and 2017 Cartoon Network series: 2 wds. |
| 60% | FERDIASHAW | 10 | Young actor who plays the title character in the 2020 movie "Artemis Fowl": 2 wds. |