| 100% | NOBLE | 5 | Chelsea ___, actress who played Laurie Marlowe, Sam's love interest on "Cheers" |
| 65% | KATE | 4 | ___ Mulgrew, actress who played Janet Eldridge, Sam's love interest on "Cheers" |
| 65% | FELDON | 6 | Barbara ___, actress who played Lauren Hudson, Sam's love interest on "Cheers" |
| 57% | VALERIE | 7 | ___ Mahaffey, actress who played an eponymous character as Sam's love interest on "Cheers" |
| 52% | RHEASEEHORN | 11 | Actress who plays Jimmy McGill's love interest, lawyer Kim Wexler, on 33-Across: 2 wds. |
| 50% | SHELLEY | 7 | ___ Long, actress who played Diane Chambers, the barmaid and Sam's love interest in the '80s sitcom "Cheers" |
| 46% | AMBERHEARD | 10 | Actress who plays Arthur Curry's love interest Mera in "Aquaman": 2 wds. |
| 44% | JAMIGERTZ | 9 | "Twister" actress who played Michael's love interest Star in "The Lost Boys": 2 wds. |
| 44% | DONNA | 5 | ___ McKechnie, actress who played Debra, Sam's ex-wife on "Cheers" |
| 43% | GWYNETHPALTROW | 14 | "The Avengers" actress who played Shakespeare's love interest, Viola, in "Shakespeare in Love": 2 wds. |
| 42% | BRITTANYMURPHY | 14 | Actress who played Eminem's love interest in "8 Mile," and met an untimely death, aged only 32: 2 wds. |
| 42% | DEBBIEREYNOLDS | 14 | "The Singing Nun" actress who played the star's love interest in "Singin' in the Rain": 2 wds. |
| 42% | ARIANADEBOSE | 12 | "West Side Story" actress who plays Kraven's love interest, the priestess Calypso, in "Kraven the Hunter": 2 wds. |
| 42% | TAYE | 4 | Diggs who plays Cookie's love interest on "Empire" |
| 41% | DORIS | 5 | Actress Roberts who played Ray's mother on "Everybody Loves Raymond" |
| 41% | DIANE | 5 | Sam's love, on Cheers |
| 41% | DUNST | 5 | Actress who plays Spiderman's love |
| 41% | VICTORIA | 8 | ___ Pedretti, "The Haunting of Bly Manor" actress who plays Love Quinn on "You" |
| 41% | HYER | 4 | Actress Martha who played Sinatra's love interest in "Some Came Running" |
| 40% | DORISROBERTS | 12 | "Remington Steele" actress who played grandmother Marie Barone on "Everybody Loves Raymond" (2 wds.) |
| 40% | MOOREHEAD | 9 | Actress who played Endora on TV's "Bewitched" |
| 40% | SHELLEYLONG | 11 | "Cheers" actress who played Jay's ex-wife DeDe on "Modern Family": 2 wds. |
| 39% | DREW | 4 | Actress who played Sheila on Netflix's "Santa Clarita Diet" |
| 39% | TINALOUISE | 10 | Actress who played Ginger on "Gilligan's Island": 2 wds. |
| 39% | MJRODRIGUEZ | 11 | Actress who plays Blanca on FX's "Pose": 2 wds. |
| 38% | SUZANNESOMERS | 13 | Actress who played Chrissy Snow on "Three's Company" (2 wds.) |
| 38% | MOLLYRINGWALD | 13 | Actress who played Sam Baker in the 1984 film "Sixteen Candles" and Mary Andrews on "Riverdale" in 2019: 2 wds. |
| 38% | LILIREINHART | 12 | Actress who plays Betty on the CW's "Riverdale": 2 wds. |
| 38% | SALLYSTRUTHERS | 14 | Actress who played Archie's daughter Gloria on 16-Across: 2 wds. |
| 38% | ROWANBLANCHARD | 14 | Actress who plays Topanga's daughter Riley on 33-Across: 2 wds. |