| 100% | MONOXIDES | 9 | Chemical compounds with just one oxygen atom |
| 45% | MONOXIDES | 9 | There's just one atom of oxygen in these molecules |
| 40% | LYE | 3 | Chemical compound with the formula NaOH |
| 39% | ENOL | 4 | Compound with a doubly linked carbon atom |
| 39% | OAR | 3 | Propeller with just one blade |
| 39% | BINGE | 5 | Not stop with just one episode |
| 39% | OXIDE | 5 | Chemical compound of oxygen |
| 38% | ENOL | 4 | Compound with a double-bonded carbon atom |
| 38% | ENOL | 4 | Compound with a doubly-linked carbon atom |
| 38% | ONE | 3 | ___-trick pony (person with just one talent) |
| 38% | STAR | 4 | A pan might come with just one |
| 38% | UNICYCLE | 8 | Human-powered vehicle with just one wheel |
| 38% | SOLOS | 5 | Parts of songs with just one instrument |
| 38% | ISOMER | 6 | Compound with a chemical "twin" |
| 38% | ENOL | 4 | Compound with two carbon atoms |
| 38% | PENTANE | 7 | Compound with five carbon atoms |
| 37% | BASILISK | 8 | King of Serpents, kills with just one glance |
| 37% | ISOMERS | 7 | Compounds with same atoms differently arranged |
| 36% | ONTHEEYE | 8 | Easy __, nice to look at with just one sight organ |
| 36% | ISOMER | 6 | Similar compound with different atom arrangement |
| 36% | ENOL | 4 | Compound with double-bonded carbon atoms |
| 36% | TNT | 3 | Explosive compound with three hydrogen atoms |
| 35% | ISOMER | 6 | Compound with the same atoms in a different arrangement |
| 35% | KETONE | 6 | Organic compound with a double-bonded oxygen |
| 34% | ISOMER | 6 | Compound with the same number of atoms in a different arrangement |
| 34% | FUME | 4 | Noxious vapor (yes, just one; work with me here) |
| 33% | DIOXIDE | 7 | One carbon atom and two oxygen atoms: carbon __ |
| 33% | DIOXIDES | 8 | Oxides with two atoms of oxygen |
| 33% | DEADWE | 6 | With 8-Down, literally, one just taking up space |
| 32% | UNO | 3 | Card game where you shout the game's name when you're left with just one card |