| 100% | PUNKYBREWSTER | 13 | Chicago-based 1984-1988 sitcom starring Soleil Moon Frye: 2 wds. |
| 46% | FAMILYMATTERS | 13 | Chicago-based 1989-1998 sitcom starring Jaleel White: 2 wds. |
| 46% | GOODTIMES | 9 | Chicago-based 1974-1979 sitcom starring Esther Rolle: 2 wds. |
| 39% | PUNKYBREWSTER | 13 | 2021 Peacock reboot of a 1980s sitcom that featured a grown-up Soleil Moon Frye: 2 wds. |
| 37% | SHAKEITUP | 9 | Chicago-based 2010-2013 sitcom starring Zendaya: 3 wds. |
| 37% | MODERNFAMILY | 12 | ABC sitcom starring 49-Across: 2 wds. |
| 37% | NIGHTCOURT | 10 | 1984-1992 sitcom starring 18-Across, 33-Across, and John Larroquette (2 wds.) |
| 37% | ATO | 3 | "___ Z" (NBC sitcom starring Ben Feldman): 2 wds. |
| 36% | THENANNY | 8 | 1990s sitcom starring Fran Drescher: 2 wds. |
| 36% | HOTIN | 5 | With 15-Across, TV Land sitcom starring 33-Across: 2 wds. |
| 36% | ANGIETRIBECA | 12 | TBS sitcom starring 32-Across as a police detective: 2 wds. |
| 36% | THEUPSHAWS | 10 | Netflix sitcom starring Kim Fields as family matriarch Regina: 2 wds. |
| 36% | UGLYBETTY | 9 | 2000s sitcom starring 35-Across as a magazine assistant: 2 wds. |
| 36% | BOJACKHORSEMAN | 14 | Netflix animated series about a washed-up sitcom star: 2 wds. |
| 36% | SISTERSISTER | 12 | '90s sitcom starring Tia and Tamera Mowry: 2 wds. |
| 36% | ATA | 3 | "One Day ___ Time" (rebooted sitcom starring Rita Moreno): 2 wds. |
| 35% | BOSOMBUDDIES | 12 | 1980-1982 sitcom starring Tom Hanks, before he was famous: 2 wds. |
| 34% | SAMANTHAWHO | 11 | 2007-2009 ABC sitcom starring Christina Applegate as a recovering amnesiac: 2 wds. |
| 34% | THEOFFICE | 9 | Emmy-winning sitcom starring Mindy Kaling (birthday today) as Kelly Kapoor": 2 wds. |
| 34% | SCHITTSCREEK | 12 | 2015-2020 sitcom starring Catherine O'Hara as actress Moira Rose: 2 wds. |
| 33% | TVCAMERA | 8 | What sitcom stars and reporters stand in front of to be recorded: 2 wds. |
| 33% | SUDDENLYSUSAN | 13 | 1996-2000 sitcom starring 15-Across as a magazine writer in San Francisco: 2 wds. |
| 33% | MAJORDAD | 8 | 1989-1993 CBS sitcom starring Gerald McRaney as a military man with stepkids: 2 wds. |
| 33% | MCHALESNAVY | 11 | 1962-1966 sitcom starring Ernest Borgnine as lieutenant commander of a military vessel: 2 wds. |
| 33% | TROPHYWIFE | 10 | ABC sitcom starring Malin Akerman and Bradley Whitford which was canceled after one season: 2 wds. |
| 32% | ROSEANNEBARR | 12 | 1990s sitcom star who was the subject of a Comedy Central Roast in 2012: 2 wds. |
| 32% | VAMPIRESLAYER | 13 | "Buffy the ___," sitcom starring Sarah Michelle Gellar which had a Halloween episode titled "Fear, Itself": 2 wds. |
| 32% | SCHITTSCREEK | 12 | Emmy-winning sitcom starring 31-Across as Moira Rose (2 wds.) |
| 32% | HALFMEN | 7 | "Two and a ___," sitcom starring Jon Cryer which had a special Thanksgiving episode in season one: 2 wds. |
| 32% | JUSTSHOOT | 9 | "___ Me!," sitcom starring David Spade as Dennis Finch for which he earned two Golden Globe nominations: 2 wds. |