| 100% | PILE | 4 | Chicago ___-1, the world's first successful nuclear reactor, built under the west stands of the original Stagg Field in 1942 |
| 29% | ATOMICPILE | 10 | The first one of these was built by Fermi and his team in 1942 |
| 27% | DUBAI | 5 | Home of the world's tallest building, completed in 2009 |
| 27% | BOSTON | 6 | Site of the world's first city marathon in 1897 |
| 27% | ATM | 3 | Installation of October 1997 in Canada's capital was the world's first talking one of these |
| 26% | NINE | 4 | Cost in dollars of the world's first TV ad in 1941 |
| 26% | CUB | 3 | Member of the ball club that plays home games in Chicago's Wrigley Field |
| 26% | JANET | 5 | First name of the original Wasp in "Ant-Man and the Wasp" |
| 26% | FERMI | 5 | Enrico ___, Italian physicist who is known for creating the world's first nuclear reactor and has an element named after him |
| 25% | MAITAI | 6 | Original ___, one of the world's most expensive cocktails served in Belfast's Merchant Hotel: 2 wds. |
| 25% | HANOI | 5 | World capital that's home to the Temple of Literature, built in 1070 |
| 25% | SEARS | 5 | Owner of the highest building in Chicago |
| 25% | HANSOLO | 7 | In the original cut of Star Wars, he shot first |
| 25% | TEXASRANGERS | 12 | AL West team that won the franchise's first-ever World Series in 2023, after 62 years: 2 wds. |
| 25% | DUBAI | 5 | Home of the tallest building in the world |
| 25% | ALI | 3 | Sports Illustrated's Sportsman of the Year in 1974 (10 years after he first became world champion) |
| 25% | FUN | 3 | First Across word in the world's first crossword |
| 25% | GREATWALL | 9 | Longest built structure in the world as of 2021 |
| 25% | LEONA | 5 | Physicist Woods who was the only women on Enrico Fermi's team that built the first nuclear reactor |
| 24% | COWPOX | 6 | Edward Jenner used it when developing the world's first successful vaccine |
| 24% | FUN | 3 | First word across in the world's first crossword (1913) |
| 24% | ELANA | 5 | ___ Meyers, who in 2015 was part of the first world champion team from the US in women's bobsled |
| 24% | HATH | 4 | Verb in the world's first telegraph message |
| 24% | ALLISTRUE | 9 | Original title of Shakespeare's "Henry VIII" (the latter not used until the First Folio in 1623) |
| 24% | EUGENE | 6 | West Coast city known as the Track and Field Capital of the World |
| 24% | NOTRE | 5 | First word of the Lord's Prayer in French |
| 24% | EYE | 3 | "The ___ of the World" (first novel in Robert Jordan's "The Wheel of Time" series) |
| 24% | BASEMAN | 7 | First ___ (Player standing in the first of the four stations in a Baseball diamond) |
| 24% | YELLOWSTONE | 11 | The world's first national park, located in Wyoming, Montana, and Idaho |
| 24% | LOUISE | 6 | __ Brown, the world's first IVF baby, born in 1978 |