| 100% | NUTS | 4 | Chock full o'___ (company where 52-Across became the first Black vice president of a major American corporation) |
| 29% | KAMALA | 6 | With 19 Across, first female Vice President of the United States of America |
| 29% | BIDEN | 5 | First Catholic vice president of the U.S. |
| 28% | HARRIS | 6 | The first female vice president-elect of the US |
| 27% | MEANY | 5 | George who was the first president of the A.F.L.-C.I.O. |
| 27% | MEANY | 5 | Labor leader George who was the first president of the A.F.L.-C.I.O. |
| 27% | TONYDUNGY | 9 | Hall-of-Famer who was the first Black head coach to win a 15 Across |
| 26% | ETHEL | 5 | Waters who was the first Black American to host a national television show |
| 26% | DONALD | 6 | The first name of a Disney Duck and a US president |
| 26% | SCOTT | 5 | Gloria ___, first black president of the Girl Scouts, 1975 |
| 26% | MAEJEMISON | 10 | The first Black female astronaut and winner of a National Achievement Scholarship in 1973: 2 wds. |
| 26% | CZECH | 5 | Nationality of a poet and playwright who became the first president of his country |
| 26% | WILLA | 5 | ___ Player, first Black woman to become president of a four-year college |
| 26% | APRIL | 5 | First full month of the Major League season |
| 26% | BULLRUN | 7 | First major battle of the American Civil War |
| 26% | STANTON | 7 | First president of the National American Woman Suffrage Association |
| 26% | ALTHEAGIBSON | 12 | In 1957, she became the first person of color to win a Wimbledon championship (2 wds.) |
| 25% | NATIVESON | 9 | First Book of the Month Club pick written by a Black American |
| 24% | KAMALA | 6 | First name of the first female US vice president |
| 24% | CALVINCOOLIDGE | 14 | US vice president who became president upon the death of Warren Harding in 1923: 2 wds. |
| 24% | JACOBY | 6 | Ellsbury who was the first Native American of Navajo descent to play in Major League Baseball |
| 24% | BULLRUN | 7 | First Battle of —, first major engagement of the American Civil War, in July 1861 |
| 24% | HARRYS | 6 | With 40-Across, US vice president who became president upon the death of Franklin D. Roosevelt in 1945: 2 wds. |
| 24% | LYNDONBJOHNSON | 14 | US vice president who became president upon the death of John F. Kennedy in 1963: 3 wds. |
| 24% | IKEA | 4 | Furniture store that was the first company to show a gay couple in an American TV commercial |
| 24% | LINCOLN | 7 | Abraham ___, 16th President of the U.S.A. and the first to sport a beard in office |
| 24% | MARIA | 5 | ___ Mitchell, astronomer who was the first female professor of astronomy and the first American to discover a comet |
| 24% | AKA | 3 | The first Black American sorority, in brief |
| 24% | THEMONOLITH | 11 | Black artifact that inspires one of the 21 Across to use a bone as a weapon |
| 24% | TONI | 4 | First name of the first Black woman to win a Nobel Prize in Literature |