| 100% | BARNARD | 7 | Christiaan __ performed the first heart transplant |
| 74% | BARNARD | 7 | Christiaan —, South African surgeon who performed the first human heart transplant in 1967 |
| 47% | CHRISTIAANBARNYARD | 18 | First person to perform a heart transplant on a chicken? |
| 43% | ADAM | 4 | Provider of the first bone transplant? |
| 41% | BTS | 3 | First Korean act to perform at the Grammys |
| 40% | ANDERSON | 8 | Singer Marian, the first African American to perform at the Met |
| 40% | SEAGULL | 7 | The —, Anton Chekhov stage play first performed in 1896 |
| 40% | BTS | 3 | First K-Pop group to perform at the Grammys |
| 40% | MAHALIA | 7 | Jackson who was the first gospel singer to perform at Carnegie Hall |
| 39% | LARK | 4 | The —, stage play by Jean Anouilh first performed in 1953 |
| 39% | NOSE | 4 | The —, Dmitri Shostakovich opera first performed in full in 1930 |
| 39% | PLEASURE | 8 | Nyman's piano piece, The Heart Asks __ First |
| 39% | CREATION | 8 | The —, oratorio by Joseph Haydn first performed in Vienna in 1798 |
| 39% | NOSE | 4 | The —, opera by Dmitri Shostakovich first performed in full in 1930 |
| 39% | BTS | 3 | First K-pop band to perform at the American Music Awards |
| 39% | INDRA | 5 | ___ Club, venue in Germany where The Beatles first performed |
| 38% | GAMBLER | 7 | The —,Prokofiev opera first performed in 1929 based on a Dostoevsky story |
| 37% | LAURABUSH | 9 | First Lady who wrote the 2010 memoir "Spoken From the Heart": 2 wds. |
| 37% | LITTLEEYOLF | 11 | 1894 play by Henrik Ibsen first performed in the following year |
| 36% | GAMBLER | 7 | The —, Sergei Prokofiev opera first performed in 1929 based on a Fyodor Dostoevsky story |
| 36% | EROICA | 6 | Work first publicly performed at the Theater an der Wien in 1805 |
| 36% | RENEE | 5 | Fleming who was the first opera singer to perform the national anthem at the Super Bowl (2014) |
| 36% | MOMSMABLEY | 10 | Trailblazing African American who was the first female comedian to perform at the Apollo Theater: 2 wds. |
| 36% | ASKS | 4 | ''The heart __ pleasure first'': Dickinson |
| 35% | LAURABUSH | 9 | Former first lady who wrote the memoir "Spoken from the Heart" (2 wds.) |
| 35% | ONE | 3 | The first |
| 35% | BARNARD | 7 | Surname of first ever heart transplant surgeon |
| 35% | BEA | 3 | Flyer that performed the world's first automatic landing on a commercial flight on June 10, 1965 (abbr.) |
| 35% | MAJORSURGERY | 12 | Heart transplant, say |