| 100% | CURE | 4 | Cinchona tree bark was among the first drugs to ___ malaria |
| 37% | THEBATHER | 9 | William Etty painting that was among the first British nudes |
| 35% | BEN | 3 | Hogan who was among the first inductees into the World Golf Hall of Fame |
| 34% | COIN | 4 | Be the first to use |
| 34% | COIN | 4 | Be the first to say |
| 34% | WIN | 3 | Be the first to finish |
| 34% | DISCOVER | 8 | Be the first to find |
| 33% | QUININE | 7 | Malaria drug found in cinchona bark |
| 33% | MECHAM | 6 | Evan ___, the first Arizona governor to be impeached |
| 33% | LAOS | 4 | Where to be among the Hmong |
| 33% | WRONGTREE | 9 | Barking up the __; to be mistaken |
| 33% | EDEN | 4 | Where the first humans were, according to the Bible |
| 33% | ABE | 3 | Nickname of the first US president to be assassinated |
| 33% | ONEPIN | 6 | It's often the first to be knocked over |
| 33% | WIN | 3 | Be the first one to finish a race, say |
| 32% | PAWN | 4 | Chess piece that's often the first to be played |
| 32% | WON | 3 | Was the first to cross the finish line |
| 32% | PELOSI | 6 | First woman to be Speaker of the House |
| 32% | LEADOFF | 7 | Be the first baseball player to bat: 2 wds. |
| 32% | JAWS | 4 | First major film to be shot on the ocean |
| 32% | CARRIERPIGEONNAMEDGIJOE | 23 | The first non-British to receive Britain's Dickin Medal for Gallantry was a _____ |
| 32% | SHAKESPEARE | 11 | Whom the first use of the nine long adjectives is credited to |
| 31% | BONO | 4 | First musician to be a ''Time'' Person of the Year |
| 31% | BLAZEATRAIL | 11 | Be the first to accomplish something (and do it spectacularly!) |
| 31% | PFIZER | 6 | First COVID-19 vaccine to be approved in the UK |
| 31% | STTERESA | 8 | First woman to be named Doctor of the Church, briefly |
| 31% | SECRETBALLOT | 12 | Australia was the first country to implement it |
| 31% | EMAIL | 5 | Clinton was the first president to send one |
| 31% | JESUIT | 6 | Francis is the first pope to be one |
| 31% | OBESITY | 7 | What the drug phentermine is used to treat |