| 100% | PUNXSUTAWNEY | 12 | City in Pennsylvania where 14-Across is set |
| 48% | NEWYORK | 7 | City in which the sitcom Seinfeld is set |
| 48% | BOSTON | 6 | City in which classic sitcom Cheers is set |
| 48% | BALTIMORE | 9 | Maryland city in which The Wire was set |
| 48% | LIMAOHIO | 8 | City in which "Glee" is set |
| 47% | TOKYO | 5 | Japanese city where "Lost in Translation" is set |
| 47% | MIAMI | 5 | City in which much of "Moonlight" is set |
| 47% | LEHI | 4 | City in Utah where Ancestry.com is headquartered |
| 47% | WACO | 4 | City in Texas where Baylor University is located |
| 47% | LIVERPOOL | 9 | City in England where the Beatles were discovered |
| 47% | AKRON | 5 | City in Ohio where LeBron James was born |
| 46% | MIAMI | 5 | City in which the 2016 film "Moonlight" is set |
| 46% | MESSINA | 7 | City in which Much Ado About Nothing is set |
| 46% | WACO | 4 | City in Texas where the Baylor University is located |
| 46% | BOSTON | 6 | City in which comedy drama Ally McBeal was set |
| 46% | LONDON | 6 | City in which most of Dickens' books are set |
| 46% | RIO | 3 | Black Orpheus is set in this city |
| 45% | EASTON | 6 | Pennsylvania city where Crayola is headquartered |
| 45% | ERIE | 4 | Pennsylvania city where "That Thing You Do!" was set |
| 44% | DUBLIN | 6 | City where "Ulysses" is set |
| 44% | COCOA | 5 | With 33-Across, Florida city in which "I Dream of Jeannie" was set |
| 44% | SALEM | 5 | City in which "One Flew Over the Cuckoo's Nest" is set |
| 44% | OMAHA | 5 | Largest city in the state where Lincoln is the capital |
| 44% | IOWA | 4 | Where River City is, in "The Music Man" |
| 44% | BETHLEHEM | 9 | City where Jesus was born in a manger |
| 44% | PHILLY | 6 | City where "Rocky" is set, informally |
| 44% | XXXXXXXX | 8 | City where "Glee" is set (1) |
| 44% | VERSAILLES | 10 | City in Yvelines, France where the Treaty of Paris was signed in 1783 |
| 44% | VERSAILLES | 10 | City in Yvelines, France, where the Treaty of Paris was signed in 1783 |
| 43% | BALTIMORE | 9 | Seaport city in Maryland where Babe Ruth was born |