| 100% | OMAHA | 5 | City once the site of the Hotel Fontenelle, where John F. Kennedy stayed during his 1960 presidential campaign |
| 30% | BREDA | 5 | City in the Netherlands where Charles II of England resided during his exile |
| 29% | DALLAS | 6 | City where John F. Kennedy was assassinated |
| 26% | TOM | 3 | ___ Kitten, Presidential pet cat that belonged to the 35th POTUS, John F. Kennedy |
| 26% | BILLIE | 6 | ___ and Debbie, Presidential pet hamsters that belonged to the 35th POTUS, John F. Kennedy |
| 25% | LEEHARVEY | 9 | & 18D Assassin of US president John F Kennedy according to the 1964 Warren Commission report |
| 24% | TREETOPS | 8 | Hotel in Aberdare National Park, Kenya, where Princess Elizabeth stayed with the Duke of Edinburgh in 1952 |
| 24% | MITCHLANDRIEU | 13 | Former mayor of New Orleans honored with the 2018 John F. Kennedy Profile in Courage Award (2 wds.) |
| 24% | ROME | 4 | Site of the 1960 Olympics |
| 23% | NANCYPELOSI | 11 | Speaker of the House honored with the 2019 John F. Kennedy Profile in Courage Award (2 wds.) |
| 23% | LYNDONBJOHNSON | 14 | US vice president who became president upon the death of John F. Kennedy in 1963: 3 wds. |
| 23% | MANILA | 6 | Site of the presidential Malacanang Palace |
| 23% | ROME | 4 | Site of the 1960 Summer Olympics |
| 23% | AQUINCUM | 8 | Roman city on the site of modern-day Budapest |
| 23% | TEXASA&M | 8 | Site of the George Bush Presidential Library |
| 23% | IONIA | 5 | Site of the ancient city of Miletus |
| 23% | UDAIPUR | 7 | City in Rajasthan, India; once the capital of the kingdom of Mewar |
| 23% | PARAMARIBO | 10 | Capital that's the site of the Gouvernementsgebouw presidential residence |
| 23% | CAVE | 4 | Where a bat might stay during the day |
| 23% | CORINTH | 7 | Greek city, the site of an ancient canal |
| 23% | CINCINNATI | 10 | City where 46-Across played college basketball and the first 11 years of his pro basketball career |
| 23% | CUZCO | 5 | Peruvian city that was once the capital of the Inca Empire |
| 23% | HENRYVI | 7 | The Wars of the Roses began during his reign |
| 23% | LAPAZ | 5 | Site of the Casa Grande del Pueblo presidential residence |
| 22% | OXFORD | 6 | English city, site of the Ashmolean Museum |
| 22% | ATHENS | 6 | Ancient Greek city; site of the Parthenon |
| 22% | STPAULS | 7 | The cathedral that sits upon Ludgate Hill, once the site of an old jail |
| 22% | TIRANA | 6 | Capital that's the site of the Pallati i Brigadave presidential residence |
| 22% | DUBLIN | 6 | Capital that's the site of the Aras an Uachtarain presidential residence |