| 100% | SSRI | 4 | Class of medication whose second "S" stands for serotonin |
| 45% | ESL | 3 | Course whose S stands for "Second" |
| 37% | EOS | 3 | Lip balm brand whose S stands for "Smooth" |
| 36% | LBS | 3 | Units whose name's first letter stands for an ancient-Roman unit of measurement |
| 35% | ASL | 3 | Its S stands for "Sign" |
| 34% | SSRI | 4 | Class of medication often used to treat depression (Abbr.) |
| 33% | STALLS | 6 | Stands for sale of goods |
| 33% | NSA | 3 | Government org. whose name's second letter stands for the same thing as 22-Across's second letter |
| 33% | SAT | 3 | What S stands for in "SNL," for short |
| 33% | SINE | 4 | What the S of "sohcahtoa" stands for |
| 33% | SOVIET | 6 | What the first S stood for in USSR |
| 32% | PRISONER | 8 | POW stands for __ of war |
| 32% | METALLICA | 9 | Rock band whose cover version of "Stone Cold Crazy" won the second-ever Grammy Award for Best Metal Performance |
| 32% | GREATEST | 8 | GOAT stands for __ of all time |
| 31% | BENNETT | 7 | Tony whose statue stands in front of San Francisco’s Fairmont Hotel |
| 31% | NORTH | 5 | What the second letter of 10-Down stands for |
| 31% | FRIEND | 6 | What the second letter of 7-Down stands for |
| 31% | ONCE | 4 | What the second "O" of "YOLO" stands for |
| 31% | AREA | 4 | What "A" might stand for in geometry class |
| 30% | EOM | 3 | Three letters that stand for end of message |
| 30% | BFF | 3 | Its second F stands for "forever" |
| 30% | DEANRUSK | 8 | U.S. secretary of state tied for the second-longest time in office |
| 30% | CAL | 3 | What the second letter of 17-Down stands for: Abbr. |
| 30% | SIERRA | 6 | It stands for S in the NATO phonetic alphabet |
| 30% | IOUS | 4 | Their second letter stands for 12-Down |
| 30% | TUE | 3 | Second day of the workweek, for short |
| 30% | TUESDAY | 7 | Second part of the workweek, for many |
| 30% | STOPWATCHES | 11 | Counters of seconds for races |
| 30% | NATO | 4 | Grp. whose members account for more than 50% of the world's defense spending |
| 30% | BRAVE | 5 | Willing to stand up for one's beliefs in the face of adversity, say |