| 100% | MRMAGOO | 7 | Classic cartoon character with comically poor vision: 2 wds. |
| 48% | BUGSBUNNY | 9 | Classic cartoon character who says "What's up, Doc?": 2 wds. |
| 42% | JUDYJETSON | 10 | Cartoon character with a black hair bow who attends Orbit High School (2 wds.) |
| 41% | MAGGIESIMPSON | 13 | Cartoon character with a blue hair bow whose long-running series debuted in 1989 (2 wds.) |
| 41% | CHUCKIEFINSTER | 14 | Nickelodeon cartoon character with red hair whose best friend is Tommy Pickles (2 wds.) |
| 40% | CANDYLAND | 9 | Classic board game with characters named for sweet treats: 2 wds. |
| 40% | HELLOKITTY | 10 | Cartoon character with a red hair bow who was appointed a children's ambassador by UNICEF (2 wds.) |
| 40% | PRINCESSMERIDA | 14 | Disney cartoon character with red hair whose best friend is a horse named Angus (2 wds.) |
| 40% | BOOP | 4 | Betty ___, a classic cartoon character with trademark large eyes and curly hair |
| 39% | YOGIBEAR | 8 | Cartoon character who lives in Jellystone Park: 2 wds. |
| 37% | STEWIEGRIFFIN | 13 | Cartoon baby with attitude on "Family Guy": 2 wds. |
| 37% | ERICCARTMAN | 11 | Cartoon boy with attitude on "South Park": 2 wds. |
| 37% | FIONACOYNE | 10 | 50-Across character with a drinking problem: 2 wds. |
| 36% | COMICSANS | 9 | Typeface that resembles a cartoon character's dialogue: 2 wds. |
| 36% | JOEYTRIBBIANI | 13 | "Friends" character with the catchphrase "How YOU doin'?": 2 wds. |
| 36% | EAGLEEYE | 8 | Person with unusually acute vision: 2 wds. |
| 35% | NEDFLANDERS | 11 | Mustachioed cartoon character who lives next door to Homer Simpson: 2 wds. |
| 35% | YOGIBEAR | 8 | Picnic basket stealing cartoon character who lives in Jellystone Park: 2 wds. |
| 35% | EMILYLITELLA | 12 | Gilda Radner's early "SNL" character with the catchphrase "Never mind": 2 wds. |
| 35% | BARNEYSTINSON | 13 | "How I Met Your Mother" character with the catchphrase "Suit up!": 2 wds. |
| 34% | JOECOOL | 7 | Cartoon character with shades |
| 34% | SHELDONCOOPER | 13 | "The Big Bang Theory" character with the catchphrase "Bazinga!": 2 wds. |
| 33% | MEREDITHGREY | 12 | ABC TV character with a colorful last name, played by Ellen Pompeo since 2005: 2 wds. |
| 33% | HAGAR | 5 | Cartoon character with a helmet |
| 33% | SMURFETTE | 9 | Cartoon character with feminine wiles |
| 33% | SPONGEBOB | 9 | Cartoon character with square pants |
| 33% | BARTSIMPSON | 11 | Fox cartoon boy with attitude who says "Cowabunga": 2 wds. |
| 33% | ODIE | 4 | Classic cartoon character originally named Spot |
| 33% | ELMERFUDD | 9 | Cartoon character with a big gun |
| 33% | SNOOPY | 6 | Cartoon character with a big nose |