| 100% | ACUMEN | 6 | Clear understanding of some area or industry |
| 38% | SECRET | 6 | With 46-Across, some areas in Clue … or a hint to the first, fourth, twelfth and fifteenth rows of this puzzle |
| 37% | UFOS | 4 | Subjects of some Area 51 conspiracy theories: Abbr. |
| 36% | OPENSEAS | 8 | Clear sailing areas … or, homophonically, a feature of 16-, 23-, 39- and 52-Across (and every clue in this puzzle!) |
| 36% | SWATHES | 7 | Large areas or strips of land |
| 36% | EVACUATE | 8 | Clear area of people |
| 36% | EVACUATED | 9 | Cleared area of people |
| 35% | DEREG | 5 | Goal of some industry lobbyists, for short |
| 35% | EXONERATE | 9 | Clear of wrongdoing or crimes |
| 35% | SOHO | 4 | Area of London or Manhattan |
| 35% | MINING | 6 | The act, process, or industry of extracting ores |
| 35% | EXTENSIVE | 9 | Covering a large area or base of knowledge |
| 35% | TWANGS | 6 | Features of some country-music singers or banjos |
| 35% | MEMEACCOUNT | 11 | Source of some popular Instagram or Twitter postings |
| 35% | SOX | 3 | Part of some "Red" or "White" uniforms |
| 34% | TELLTALE | 8 | Clear indications or signs of something |
| 34% | WETLAND | 7 | Area consisting of marshes or swamps |
| 34% | LEA | 3 | Area of grassy or arable land |
| 34% | STEEP | 5 | Descriptive of some bills or hills |
| 34% | PEERS | 5 | Some sources of pressure or review |
| 34% | DANK | 4 | Quality of some memes or weed |
| 34% | CITRUSNOTES | 11 | Features of some wines or perfumes |
| 34% | POLLENCOUNTRY | 13 | Area allergy sufferers should steer clear of? |
| 34% | SOHO | 4 | Area of London or Manhattan, for short |
| 34% | MUSHROOMS | 9 | Some of them are cremini or porcini |
| 34% | TITAN | 5 | Giant of industry or mythology |
| 34% | EYED | 4 | Follower of clear or cross |
| 33% | GREENBELT | 9 | Area of countryside around a town or city |
| 33% | NUCLEAR | 7 | Some forms of life survive the atomic or __ blasts |
| 32% | CITYSCAPE | 9 | Artwork or photograph of an urban area |