| 100% | RCA | 3 | Co. whose camera broadcast the first live video from space |
| 33% | HARRYTRUMAN | 11 | President whose State of the Union Address was the first to be broadcast live on television (2 wds.) |
| 33% | REMOTE | 6 | Live TV broadcast away from the studio |
| 33% | LYNDONJOHNSON | 13 | President whose State of the Union Address was the first to be broadcast live on prime-time television (2 wds.) |
| 31% | YOUTUBE | 7 | Website whose first video was "Me at the zoo" |
| 31% | CSPAN | 5 | First network to broadcast a live session of the House of Representatives |
| 31% | MTV | 3 | Network whose first video was "Video Killed the Radio Star" |
| 31% | MTV | 3 | Channel whose first video was "Video Killed the Radio Star" |
| 31% | TNT | 3 | Cable channel whose first broadcast was "Gone With the Wind" |
| 30% | TCM | 3 | Channel whose first broadcast, in 1994, was “Gone with the Wind” |
| 30% | ABBA | 4 | Pop group whose name derives from the initials of its members' first names |
| 29% | HBO | 3 | Cable channel whose first broadcast, in 1972, was the movie "Sometimes a Great Notion" |
| 29% | ENYA | 4 | Irish singer whose stage name comes from the pronunciation of her first name, Eithne |
| 29% | GIL | 3 | Currency in the video game "Final Fantasy" whose name comes from an old Dutch coin |
| 28% | COLECO | 6 | Old video game company whose first four letters match the middle four letters of 115 Across |
| 28% | SIMS | 4 | Video-game characters whose "lives" are controlled by the players |
| 27% | SPUTNIK | 7 | The first artificial satellite sent into space |
| 27% | ARMANI | 6 | First living designer exhibited at the Guggenheim |
| 27% | DENNIS | 6 | __ Tito, the first space tourist |
| 27% | CBS | 3 | Co. that first went on the air in 1927 with the Howard L. Barlow Orchestra from station WOR in Newark, NJ |
| 27% | CNN | 3 | Its first news broadcast was co-anchored by the husband-and-wife team of Dave Walker and Lois Hart |
| 27% | ALEKSEI | 7 | Leonov who was the first man to walk in space |
| 27% | NASA | 4 | Hit song by Ariana Grande from her 2019 album whose title is named after the U.S. space agency |
| 27% | FRUITFLY | 8 | First living creature sent into Space, in 1947 |
| 27% | COCACOLA | 8 | The first soft drink consumed in outer space |
| 27% | SALLYRIDE | 9 | The first American woman to travel to space |
| 27% | OBI | 3 | The first name of Kenobi, from "Star Wars" |
| 27% | HEAD | 4 | The first blank in this phrase: From ___ to ___ |
| 27% | ANNALEE | 7 | Fisher, the first mother in space |
| 27% | GAGARIN | 7 | Yuri __, the first cosmonaut in space |