| 100% | STEVEWOZNIAK | 12 | Co-founder of Apple and noted philanthropist who did a guest appearance on "The Big Bang Theory": 2 wds. |
| 66% | ELONMUSK | 8 | CEO of SpaceX and product architect of Tesla who did a guest appearance on "The Big Bang Theory": 2 wds. |
| 61% | ADAMWEST | 8 | Batman actor from the 1960s who did a guest appearance on "The Big Bang Theory": 2 wds. |
| 43% | CHUCKLORRE | 10 | Creator of "Two and a Half Men" and "The Big Bang Theory," who is also the co-creator of CBS's new show "Young Sheldon": 2 wds. |
| 39% | BRITNEYSPEARS | 13 | "Princess of Pop" who had a guest appearance twice in "HIMYM" in the episodes "Ten Sessions" and "Everything Must Go" : 2 wds. |
| 38% | WIL | 3 | Actor Wheaton who made several guest appearances on "The Big Bang Theory" |
| 37% | WIL | 3 | Actor Wheaton who has guest appearances on "The Big Bang Theory" |
| 36% | YOUNGSHELDON | 12 | "The Big Bang Theory" prequel about one of the scientists as a boy (2 wds.) |
| 36% | MAYIMBIALIK | 11 | "The Big Bang Theory" actress who earned a doctorate in neuroscience from 33-Down: 2 wds. |
| 36% | KATEYSAGAL | 10 | "Sons of Anarchy" actress who played Penny's mother on "The Big Bang Theory" (2 wds.) |
| 36% | MAYIMBIALIK | 11 | Former "Blossom" and "The Big Bang Theory" star who co-hosts "Jeopardy!" (2 wds,) |
| 35% | WIL | 3 | Wheaton with guest appearances on "The Big Bang Theory" |
| 35% | WIL | 3 | "Star Trek: TNG" actor Wheaton who made several guest appearances on "The Big Bang Theory" |
| 35% | GIGIHADID | 9 | Supermodel with 35 appearances on the cover of "Vogue" who co-hosts 32-Across (2 wds.) |
| 34% | MILAKUNIS | 9 | "Friends With Benefits" actress, who made a guest appearance on boyfriend Ashton Kutcher's "Two And A Half Men": 2 wds. |
| 34% | ALICIAKEYS | 10 | American musician who co-founded and is the Global Ambassador of the nonprofit organization "Keep a Child Alive": 2 wds. |
| 34% | WILWHEATON | 10 | "Star Trek: The Next Generation" actor who guest stars as himself on "The Big Bang Theory" (2 wds.) |
| 34% | HEIDIKLUM | 9 | German model and TV personality who had a guest appearance in "How I Met Your Mother" in the episode called "The Yips": 2 wds. |
| 34% | JIMPARSONS | 10 | Actor who plays Sheldon on "The Big Bang Theory" (2 wds.) |
| 34% | JOHNNYGALECKI | 13 | Actor who plays Leonard on "The Big Bang Theory" (2 wds.) |
| 34% | KALEYCUOCO | 10 | Actress who plays Penny on "The Big Bang Theory" (2 wds.) |
| 34% | JIMPARSONS | 10 | "The Big Bang Theory" actor who played Michael in "The Boys in the Band": 2 wds. |
| 33% | JIMPARSONS | 10 | Actor who portrayed Sheldon Cooper in "The Big Bang Theory," and is the narrator in "Young Sheldon": 2 wds. |
| 33% | KALEYCUOCO | 10 | "The Big Bang Theory" actress who says "Every trip is a big deal" in Priceline.com commercials (2 wds.) |
| 33% | JUDDHIRSCH | 10 | "Superior Donuts" actor who guest stars as Leonard's dad on "The Big Bang Theory" (2 wds.) |
| 33% | LAURIEMETCALF | 13 | "Lady Bird" actress who guest stars as Sheldon's mom on "The Big Bang Theory" (2 wds.) |
| 33% | TAKEI | 5 | "Star Trek" actor George who has had cameos on "The Big Bang Theory" and "King of the Nerds" |
| 33% | MANDYPATINKIN | 13 | Tony- and Emmy-winning actor who was a guest on the "On Broadway" episode of "Finding Your Roots" in 2021 (2 wds.) |
| 32% | LORRE | 5 | Chuck who co-created "The Big Bang Theory" and "Two and a Half Men" |
| 32% | JIMPARSONS | 10 | Star of "The Big Bang Theory": 2 wds. |