| 100% | ETHAN | 5 | Coen brother who didn’t direct 2021’s “The Tragedy of Macbeth” |
| 42% | JOEL | 4 | "The Tragedy of Macbeth" screenwriter/director Coen |
| 38% | JOELCOEN | 8 | Elder of the brothers who directed Fargo film |
| 35% | PEYTONMANNING | 13 | Two-time Super Bowl champion quarterback with a two-time Super Bowl champion quarterback brother who is a member of the Pro Football Hall of Fame's Class of 2021 (2 wds.) |
| 35% | COEN | 4 | Last name of the brothers who directed "O Brother, Where Art Thou?" |
| 35% | ELIOT | 5 | T. S. ___, poet who wrote "The Love Song of J. Alfred Prufrock" |
| 35% | KARL | 4 | Marx who wasn't one of the Marx Brothers |
| 35% | RIC | 3 | Documentarian Burns who's the brother of Ken |
| 34% | RAUL | 4 | Fidel Castro's brother who served as the President of Cuba |
| 34% | TITO | 4 | Michael Jackson's brother who was part of the "Jackson 5" |
| 34% | ALDA | 4 | Alan who directed the final episode of "M*A*S*H" |
| 34% | ELON | 4 | Musk who was Time's Person of the Year in 2021 |
| 34% | JUNGLE | 6 | Brothers who released Done by the Forces of Nature |
| 34% | COEN | 4 | "The Tragedy of Macbeth" director Joel |
| 34% | COEN | 4 | “The Tragedy of Macbeth” director Joel |
| 34% | CHLOEZHAO | 9 | "Songs My Brothers Taught Me" writer/director who directed the 2020 film adaptation of 45-Across by 29-Across (2 wds.) |
| 33% | HARPO | 5 | Marx brother who didn't speak |
| 33% | STEARNS | 7 | The S. of T.S. Eliot |
| 33% | ETHAN | 5 | One of the directing Coens |
| 33% | POMPEO | 6 | Ellen ___, actress from "Grey's Anatomy" who has directed two episodes of the series |
| 33% | ZEPPO | 5 | Marx brother who typically had the role of straight man |
| 32% | MAIA | 4 | Olympic ice dancer Shibutani who's part of the "Shib Sibs" with her brother Alex |
| 32% | EDW | 3 | Prince who's the younger brother of Chas. and who is uncle to Wm. |
| 32% | GUMMO | 5 | Marx brother who didn't appear in their movies |
| 32% | FREDSAVAGE | 10 | Actor who played Kevin Arnold on the original 32-Across and who directed the first episode of the 2021 reboot of 32-Across (2 wds.) |
| 32% | LUC | 3 | Jacquet who directed "March of the Penguins" |
| 32% | WES | 3 | Craven who directed "Music of the Heart" |
| 32% | EDGAR | 5 | Wright who directed “Shaun of the Dead” |
| 32% | COREYHAWKINS | 12 | "In the Heights" actor who plays Macduff in "The Tragedy of Macbeth" (2 wds.) |
| 32% | SIMONEBILES | 11 | Olympic gold medal gymnast who was Time's Athlete of the Year in 2021 (2 wds.) |