| 100% | CAROLBURNETT | 12 | Comedian and variety show host who was awarded the Mark Twain Prize in 2013: 2 wds. |
| 69% | JAYLENO | 7 | Former "Tonight Show" host who was awarded the Mark Twain Prize in 2014: 2 wds. |
| 58% | TINAFEY | 7 | "30 Rock" star who was awarded the Mark Twain Prize in 2010: 2 wds. |
| 52% | RICHARDPRYOR | 12 | "Silver Streak" star who was awarded the very first Mark Twain Prize for American Humor in 1998: 2 wds. |
| 49% | LORNEMICHAELS | 13 | "Saturday Night Live" creator who was awarded the Mark Twain Prize for American Humor (2 wds.) |
| 48% | EDDIEMURPHY | 11 | Former "Saturday Night Live" regular who was awarded the Mark Twain Prize for American Humor (2 wds.) |
| 48% | WILLFERRELL | 11 | Former "Saturday Night Live" regular who was awarded the Mark Twain Prize for American Humor (2 wds.) |
| 48% | CAROLBURNETT | 12 | Actress and comedian who was awarded the 44-Across in 2013 (2 wds.) |
| 48% | JONSTEWART | 10 | Comedian who was the host of "The Daily Show" till 2015, and has hosted 2 Grammy Award ceremonies: 2 wds. |
| 47% | CONAN | 5 | O’Brien who was awarded the Mark Twain Prize for American Humor, in 2025 |
| 44% | DAVECHAPPELLE | 13 | "A Star Is Born" actor who won the Mark Twain Prize in 2019: 2 wds. |
| 43% | LINUSPAULING | 12 | American chemist who was awarded the Nobel Peace Prize in 1962: 2 wds. |
| 43% | BILLCOSBY | 9 | Comedian who was awarded the Spingarn Medal in 1985: 2 wds. |
| 43% | MILTONBERLE | 11 | Early TV variety show host who was a charter inductee into the Television Hall of Fame: 2 wds. |
| 43% | TONIMORRISON | 12 | "Beloved" novelist who was awarded the Nobel Prize in Literature in the year 1993: 2 wds. |
| 41% | ELLENDEGENERES | 14 | Comedian and daytime talk host who appeared in the "Girls Like You" video: 2 wds. |
| 41% | ADAMSANDLER | 11 | "Grown Ups" actor who won the Mark Twain Prize in 2023: 2 wds. |
| 41% | MOTHERTERESA | 12 | Albanian-Indian catholic nun who was awarded the Nobel Peace Prize in 1979: 2 wds. |
| 41% | BOBDYLAN | 8 | Singer/songwriter who was awarded the 2016 Nobel Prize in Literature (2 wds.) |
| 41% | NELSONMANDELA | 13 | South African anti-apartheid revolutionary who was awarded the Nobel Peace Prize in 1962: 2 wds. |
| 41% | JOHNLEWIS | 9 | Politician and civil rights leader who was awarded the Spingarn Medal in 2002: 2 wds. |
| 40% | SETHMEYERS | 10 | "Late Night" host who hosted the ESPY Awards in 2010 and 2011: 2 wds. |
| 39% | EDDIEMURPHY | 11 | "The Nutty Professor" actor and "SNL" star who won the Mark Twain Prize for American Humor in 2015: 2 wds. |
| 39% | BARACKOBAMA | 11 | 44th President of the U.S. who was awarded the Nobel Peace Prize in 2009: 2 wds. |
| 39% | WOODROWWILSON | 13 | 28th President of the U.S. who was awarded the Nobel Peace Prize in 1919: 2 wds. |
| 39% | JIMMYCARTER | 11 | 39th President of the U.S. who was awarded the Nobel Peace Prize in 2002: 2 wds. |
| 39% | WILLFERRELL | 11 | "Elf" actor and "Saturday Night Live" star who won the Mark Twain Prize for American Humor in 2011: 2 wds. |
| 39% | ALTONBROWN | 10 | American chef, who is the host of popular shows like "Good Eats" and "Iron Chef America": 2 wds. |
| 39% | LORNEMICHAELS | 13 | "SNL" producer who won the Mark Twain Prize for American Humor in 2004: 2 wds. |
| 38% | LENAHORNE | 9 | Jazz singer who was awarded the Spingarn Medal in 1983: 2 wds. |