| 100% | SAMANTHABEE | 11 | Comedian who hosts 36-Across: 2 wds. |
| 70% | MARCMARON | 9 | Comedian who hosts the "WTF" podcast: 2 wds. |
| 69% | CHRISHARDWICK | 13 | Comedian who hosts "Talking Dead" on AMC: 2 wds. |
| 64% | JOANRIVERS | 10 | Late comedian who hosted "The Late Show" on Fox from 1986-1987: 2 wds. |
| 63% | JAYPHAROAH | 10 | Former "SNL" comedian who hosts the Fox game show "The Quiz With Balls": 2 wds. |
| 63% | KENANTHOMPSON | 13 | "Saturday Night Live" comedian who hosted the Nickelodeon Kids' Choice Awards in 2021: 2 wds. |
| 62% | LESLIEJONES | 11 | Former "Saturday Night Live" comedian who hosts the prime-time game show "Supermarket Sweep": 2 wds. |
| 62% | TIGNOTARO | 9 | Comedian who plays a radio host in the Amazon series "One Mississippi": 2 wds. |
| 62% | KENANTHOMPSON | 13 | "Saturday Night Live" comedian who hosted the People's Choice Awards in 2021 and 2022: 2 wds. |
| 60% | LILLYSINGH | 10 | Comedian/YouTuber who hosted NBC's "A Little Late": 2 wds. |
| 59% | CHEVYCHASE | 10 | Comedian who was the first host of 31-Across (2 wds.) |
| 59% | JOANRIVERS | 10 | Comedian who was the first woman to host a late-night talk show on a major network: 2 wds. |
| 58% | JONSTEWART | 10 | Comedian who was the host of "The Daily Show" till 2015, and has hosted 2 Grammy Award ceremonies: 2 wds. |
| 58% | GEORGECARLIN | 12 | Comedian who hosted the first episode of "Saturday Night Live" on October 11, 1975 (2 wds.) |
| 57% | MICHAELCHE | 10 | Comedian who currently co-hosts 31-Across with Colin Jost (2 wds.) |
| 57% | PAIGEDAVIS | 10 | TV personality and actress who hosts 31-Across: 2 wds. |
| 57% | HELENMIRREN | 11 | Oscar-winning British actress who hosts 34-Across: 2 wds. |
| 53% | AMYPOEHLER | 10 | "Saturday Night Live" comedian who went on to star in 24-Across and 36-/42-Across: 2 wds. |
| 53% | ROBINWILLIAMS | 13 | Comedian who stars in "The Crazy Ones": 2 wds. |
| 53% | DANECOOK | 8 | Comedian who starred in "Good Luck Chuck": 2 wds. |
| 52% | WHOOPIGOLDBERG | 14 | Comedian who's cohosted "The View" since 2007: 2 wds. |
| 52% | JOHNNYCARSON | 12 | American talk show host and comedian who hosted "The Tonight Show" for three straight decades: 2 wds. |
| 52% | SNOOPDOGG | 9 | Rapper who hosts the "GGN" podcast: 2 wds. |
| 52% | AHMADRASHAD | 11 | Former Vikings wide receiver who hosted 18-Across from 1990-2004: 2 wds. |
| 52% | BILLCOSBY | 9 | Comedian who was awarded the Spingarn Medal in 1985: 2 wds. |
| 52% | KRISTENSCHAAL | 13 | Comedian who voices Louise Belcher on "Bob's Burgers": 2 wds. |
| 52% | EUGENEMIRMAN | 12 | Comedian who voices Gene Belcher on "Bob's Burgers": 2 wds. |
| 51% | JOHNOLIVER | 10 | Comedian and late-night host who voices Steve the porcupine in 43-Across (2 wds.) |
| 51% | DAXSHEPARD | 10 | "Parenthood" actor who hosts the "Armchair Expert" podcast: 2 wds. |
| 51% | EMMABUNTON | 10 | Singer who hosts "The Great American Baking Show": 2 wds. |