| 100% | ODIE | 4 | Comics character who's asked, "Is it true you became man's best friend by bribing somebody?" |
| 37% | GEORGECOSTANZA | 14 | Character who is Jerry's best friend since high school and is played by Jason Alexander on the show "Seinfeld": 2 wds. |
| 35% | MADHATTER | 9 | Lewis Carroll character who asks "Does your watch tell you what year it is?" |
| 35% | CHARLOTTESWEB | 13 | Children's classic by 50-Across with the line, "It is not often that someone comes along who is a true friend and a good writer" (2 wds.) |
| 35% | ZOOLANDER | 9 | Film character who asks "Did you ever think that maybe there's more to life than being really, really, really ridiculously good-looking?" |
| 33% | GLINDA | 6 | Character who asks Dorothy, “Are you a good witch or a bad witch?” |
| 32% | SAM | 3 | Film character who was asked to "Play it" |
| 31% | NEMO | 4 | Fictional character who says "I am not what you call a civilized man!" |
| 31% | CHARLOTTESWEB | 13 | Children's classic with the line "It is not often that someone comes along who is a true friend and a good writer" |
| 30% | KIFF | 4 | Animated musical TV series featuring a rabbit character, Barry Buns, who is the titular character's best friend |
| 30% | PIGLET | 6 | Winnie-the-Pooh's best friend who once asked, "We'll be friends forever, won't we Pooh?" |
| 30% | DOG | 3 | Man's best friend, it's said |
| 30% | DOG | 3 | Man's best friend, it's claimed |
| 30% | BOTH | 4 | "It is not often that someone comes along who is a true friend and a good writer. Charlotte was ___," famous last line of "Charlotte's Web" |
| 30% | NED | 3 | Leeds who is Spider-Man's best friend in the MCU movies |
| 30% | ROD | 3 | I am a fisherman's best friend. I help them pull the fish once it's hooked. Who am I? |
| 29% | MOIRAROSE | 9 | "Schitt's Creek" character who says, "What you did was impulsive, capricious, and melodramatic, but it was also wrong" |
| 29% | DOG | 3 | I'm a loyal canine known to be "man's best friend." Who am I? |
| 29% | GOD | 3 | Heavenly figure Animal that is man's best friend |
| 29% | THATWASNTME | 11 | Song by 32-Across with the lyrics "I'm not asking you to move on or forget it / But these are better days" (3 wds.) |
| 29% | NOONE | 5 | Who "knows what it's like to be the bad man," according to a 1971 hit by the Who |
| 28% | DRSEUSS | 7 | Who wrote "Unless someone like you cares a whole awful lot, nothing is going to get better. It's not" |
| 28% | ANNIEHALL | 9 | Title character who sings "It Had to Be You" |
| 28% | PRYOR | 5 | Richard who in 2017 was named Best Stand-Up Comic of All Time by Rolling Stone |
| 28% | YODA | 4 | Film character who says "Named must your fear be before banish it you can" |
| 28% | YODA | 4 | Film character who says "Named must be your fear before banish it you can" |
| 28% | STARFISH | 8 | Creature who is SpongeBob's best friend Patrick |
| 28% | MASSE | 5 | It shouldn't be tried by people who aren't good at English |
| 27% | SHREK | 5 | Animated character who was Donkey's friend |
| 27% | SABLE | 5 | Silver ___, character who is one of Spider-Man's love interests in the "What If?" comics |