| 100% | PCOS | 4 | Common condition whose first two letters stand for "polycystic" |
| 57% | MEGALOMANIA | 11 | Condition whose first two letters are oddly appropriate |
| 56% | HRH | 3 | Regnal abbreviation whose first letter can stand for two different words |
| 52% | HYPERTEXT | 9 | First two letters in HTTP stand for this word |
| 47% | DEA | 3 | Agency whose first letter stands for Drug |
| 47% | VCHIP | 5 | Technology whose first letter stands for "violence" |
| 46% | XFL | 3 | Gridiron org. whose first letter did not, in fact, stand for "extreme" |
| 46% | BLT | 3 | Sandwich whose first letter stands for 11-Down |
| 45% | RNA | 3 | Genetic material whose first letter stands for "ribo" |
| 45% | SMS | 3 | Digital protocol whose first letter stands for short |
| 45% | XPLANE | 6 | Research aircraft whose first letter stands for "experimental" |
| 45% | UBOAT | 5 | Naval craft whose first letter stands for untersee |
| 44% | RNA | 3 | Genetic material whose first letter stands for "ribo" (Abbr.) |
| 43% | WEBLOG | 6 | Online journal whose first two letters are usually dropped |
| 42% | HILO | 4 | City whose first two letters are its state's postal abbreviation |
| 42% | WEBLOGS | 7 | Word meaning “online journals” whose first two letters are usually omitted |
| 42% | GEICO | 5 | Insurance company whose first letter stands for "government," though it's a private company |
| 41% | LBS | 3 | Units whose name's first letter stands for an ancient-Roman unit of measurement |
| 40% | SAT | 3 | High school hurdle whose first two letters, phonetically, sound like one of its former components |
| 40% | LSAT | 4 | Exam whose first initial stands for "Law" |
| 39% | ALCOA | 5 | Its first two letters are the chemical symbol for what it produces |
| 39% | UBOAT | 5 | Its first letter stands for "untersee" |
| 39% | IPA | 3 | Its first letter stands for "India" |
| 39% | DDT | 3 | Its first letter stands for "dichloro-" |
| 39% | HMART | 5 | Supermarket chain whose name's first letter stands for the Korean phrase han ah reum |
| 38% | TCM | 3 | Cable channel whose first initial stands for its founder |
| 37% | OCR | 3 | Tech whose last letter stands for "recognition" |
| 37% | ORALB | 5 | Brand whose last letter stands for "brush" |
| 37% | ATM | 3 | Abbreviation whose middle letter stands for "teller" |
| 37% | DIDICONN | 8 | "Grease" actress whose first name consists of the same two letters twice |