| 100% | POLISCI | 7 | Common prelaw major, informally |
| 47% | ECON | 4 | College major, informally |
| 45% | POLI | 4 | ___ sci (college major, informally) |
| 45% | SCI | 3 | Comp ___ (college major, informally) |
| 45% | PSYCH | 5 | Big college major, informally |
| 45% | POLI | 4 | ___-sci (college major, informally) |
| 45% | THEOPEN | 7 | Major tennis tourney, informally |
| 45% | PSYCH | 5 | Popular college major, informally |
| 45% | SCI | 3 | Poly ___ (college major, informally) |
| 45% | LEX | 3 | Major Manhattan thoroughfare, informally |
| 45% | NOLO | 4 | Common plea, informally |
| 45% | FAQS | 4 | Common queries, informally |
| 45% | PREMEDS | 7 | Some biology majors, informally |
| 44% | PBJS | 4 | Common lunchbox sandwiches, informally |
| 44% | GUAC | 4 | Common burrito topping, informally |
| 44% | PBJ | 3 | Common lunchbox item, informally |
| 42% | ITEN | 4 | Major thoroughfare through Houston, informally |
| 41% | BIO | 3 | Class for a physiology major, informally |
| 41% | LITCRIT | 7 | Course for an English major, informally |
| 41% | WORDDOC | 7 | Common format for an essay, informally |
| 40% | VPPICK | 6 | Major political announcement before a convention, informally |
| 40% | THEBIGS | 7 | Baseball's major leagues, informally |
| 40% | PGAS | 4 | Some major golf tournaments, informally |
| 39% | AROD | 4 | Major-league All-Star turned TV analyst, informally |
| 38% | INNIE | 5 | Most common belly button type, informally |
| 38% | OPEN | 4 | Common word in the names of major tennis tournaments |
| 38% | ECON | 4 | Many an M.B.A.'s undergrad major, informally |
| 34% | POLISCI | 7 | Major that might require International Relations and U.S. Government classes, informally |
| 31% | SNL | 3 | Chase scenes were once common here, informally |
| 30% | POLI | 4 | ___ Sci (common major, for short) |