| 100% | IKEA | 4 | Company that was the first in the U.S. to air a TV ad with a gay couple (1994) |
| 60% | IKEA | 4 | Furniture store that was the first company to show a gay couple in an American TV commercial |
| 60% | IKEA | 4 | First company to feature a gay couple in a mainstream U.S. TV ad (1994) |
| 48% | ALABAMA | 7 | Montgomery's state that was the first US state to recognize Christmas as a holiday in 1836 |
| 47% | OBERLIN | 7 | Ohio college that was the first in the U.S. to admit women |
| 47% | OBERLIN | 7 | Ohio college that was the first in the U.S. to award degrees to women |
| 44% | SLIMSHADY | 9 | "The Real ___," Eminem's first song to reach number one in the U.K, with a video that parodied several real-life celebrities: 2 wds. |
| 42% | HONDAACCORD | 11 | First car from a Japanese manufacturer to be made in the U.S. (1982) |
| 41% | YELLOWSTONE | 11 | First national park in the U.S. with parts in Wyoming that was featured in the movie "2012" |
| 40% | REBA | 4 | McEntire who is the first woman to portray Colonel Sanders in a KFC ad |
| 39% | PALM | 4 | Co. that was the first to successfully market a PDA worldwide in 1997 |
| 38% | REDDAWN | 7 | 1984 Patrick Swayze film that was the first to be released with a PG-13 rating |
| 38% | METS | 4 | M.L.B. team that was the first to trade a player for himself (Harry Chiti in 1962) |
| 38% | SCARLETT | 8 | 1994 miniseries that was a sequel to the 1939 Best Picture winner "Gone With the Wind" |
| 38% | LAPD | 4 | First law enforcement org. in the U.S. to hire a female officer (1910) |
| 37% | PSYCHO | 6 | Film where Marion was shown flushing a toilet with its contents visible - a first in the US at the time |
| 37% | LEE | 3 | Rebecca ___ Crumpler, physician who was the first African-American woman in the US to earn a medical degree |
| 37% | BLACKWELL | 9 | Elizabeth ___, British physician who was the first woman to earn a medical degree in the US |
| 37% | MARIO | 5 | First video game character to be honored with a figure in the Hollywood Wax Museum |
| 36% | TOTALECLIPSE | 12 | Event across the U.S. on 4/8/24 ... and, with 57-Across, 1983 Bonnie Tyler hit that would be apt to play during a 46-Across |
| 36% | TMZ | 3 | Hollywood website that was the first to report Michael Jackson's death in 2009 |
| 36% | MILEYCYRUS | 10 | "Party in the U.S.A." singer whose first TV series lead role was on Disney's "Hannah Montana": 2 wds. |
| 36% | RCA | 3 | Company that unveiled the first black-and-white TV in 1939 |
| 36% | RONALDREAGAN | 12 | U.S. president who was the first born in Illinois, the first to have been divorced, and the first to nominate a woman to the Supreme Court (2 wds.) |
| 36% | SMOG | 4 | Fog that has combined with excessive smoke in the air, often leading to a lot of lung diseases |
| 36% | HAMEL | 5 | Actress Veronica who was the model in the last cigarette ad shown on U.S. TV |
| 36% | PRANK | 5 | Person the Joker tried to push into a chemical vat in TV's "The Batman", despite the fact that he was the Joker's sidekick |
| 36% | LEVI | 4 | ___ Strauss & Co., denim company that was the first to manufacture blue jeans |
| 35% | DONUT | 5 | Sweet treat with a hole that is celebrated with a National Day in the US in June |
| 35% | CNN | 3 | Channel started in 1980 that was the first in the world to provide 24-hour news coverage |