| 100% | LDOPA | 5 | Component of the combo drug Sinemet |
| 63% | LDOPA | 5 | One of two components of the drug Sinemet |
| 48% | ESTROGEN | 8 | Component of the pill |
| 47% | SMALLA | 6 | Component of the "at" sign |
| 47% | MTS | 3 | Components of the Rockies: Abbr. |
| 47% | OPERAS | 6 | Components of the “Ring” cycle |
| 46% | ANIL | 4 | Component of the pigment Maya blue |
| 46% | LOCUST | 6 | Component of the eighth plague of Egypt |
| 46% | DISK | 4 | Component of the Tower of Hanoi puzzle |
| 45% | STAR | 4 | Component of the Big Dipper, for example |
| 45% | SUMAC | 5 | Component of the spice blend za'atar |
| 45% | IRIS | 4 | Colored component of the eye |
| 45% | CEE | 3 | Major component of the euro symbol |
| 45% | EGG | 3 | Poached component of the dish shakshuka |
| 44% | ESSAY | 5 | Component of the SAT that became optional in 2016 |
| 44% | RESETTLEMENT | 12 | Vital component of the global refugee process |
| 43% | INTESTINE | 9 | Large or small component of the digestive system |
| 42% | ZSA | 3 | One component of the baby pet name of Sari Gabor |
| 42% | COMMUNITY | 9 | Chance and ___ Chest cards, components of the gameplay for "Monopoly" |
| 42% | REDROCK | 7 | Component of many sandstone features in the Southwest |
| 41% | PROAMS | 6 | Components of The American Express or the AT&T Pebble Beach golf tourneys |
| 40% | CELLULOSE | 9 | The main component of the plant cell wall |
| 40% | ANTIQUARK | 9 | One of the two components of 5-Down |
| 40% | DOT | 3 | One of the three components in an ellipsis |
| 39% | SENNA | 5 | Drug from the leaves of a plant |
| 39% | PABLOESCO | 9 | Onetime head of the Medellín drug cartel |
| 38% | ELCHAPO | 7 | Nickname of the Mexican drug lord Joaquín Guzmán |
| 38% | LSD | 3 | One of the two drugs involved in candyflipping |
| 38% | CROCI | 5 | Flowers that are a source of the anti-inflammatory drug colchicine |
| 38% | RBI | 3 | One of the components of an M.L.B. Triple Crown |