| 100% | AMINO | 5 | Compound containing an NH2 group, informally |
| 44% | ENOL | 4 | Compound containing a hydroxyl group |
| 44% | ENOL | 4 | Compound containing a hydroxl group |
| 43% | AMIDE | 5 | Organic compound containing the group CONH2 |
| 40% | ENOL | 4 | Organic compound containing a hydroxyl group |
| 37% | ENOL | 4 | Suffix in compounds containing a hydroxyl group |
| 33% | TRIOXIDE | 8 | Compound containing O3 |
| 33% | DIOXIDE | 7 | Compound containing 10-Down |
| 33% | ISOMERS | 7 | Compounds containing molecular variants |
| 30% | ACIDIC | 6 | Being or containing an acid |
| 30% | JERUSALEM | 9 | City containing an Old City |
| 30% | TEXT | 4 | Message containing an emoji, often |
| 30% | FRAT | 4 | Group that takes pledges, informally |
| 30% | LINO | 4 | An old typesetting machine, informally |
| 30% | RELAY | 5 | Device that contains an electromagnet |
| 30% | TEXT | 4 | It might contain an emoji |
| 30% | DESKSET | 7 | It might contain an inbox |
| 30% | REP | 3 | Theater group, informally |
| 30% | SOPHS | 5 | Campus group, informally |
| 30% | LEGION | 6 | Veterans' group, informally |
| 30% | NLEAST | 6 | Brave group, informally? |
| 30% | FRAT | 4 | Rushing group, informally |
| 30% | FRAT | 4 | School group, informally |
| 30% | SIBS | 4 | Genealogical grouping, informally |
| 30% | DEMO | 4 | Population grouping, informally |
| 30% | GREASIER | 8 | Containing an unusual amount of grease or oil |
| 29% | BOTTLE | 6 | Glass containing an impossibly placed ship |
| 29% | EAR | 3 | Organ containing an anvil and hammer |
| 29% | MOONIES | 7 | Professors World Peace Academy group, informally |
| 29% | KOPS | 4 | Keystone ___ (1910s policemen comedy group, informally) |