| 100% | TITER | 5 | Concentration of a substance in a solution |
| 65% | TITER | 5 | Concentration of a substance |
| 57% | TITRATES | 8 | Determines the concentration of a dissolved substance |
| 57% | FOAM | 4 | Frothy substance in a glass of beer |
| 56% | SALINE | 6 | A solution of salt in water |
| 56% | TITER | 5 | Strength of a solution, in chemistry |
| 55% | PROBLEM | 7 | Situation in need of a solution |
| 53% | SAP | 3 | Solution of sugars and mineral salts that circulates in a plant |
| 53% | CHARCOAL | 8 | Lumps of a hard black substance used in barbecues |
| 51% | OOBLECK | 7 | Gooey green substance in the title of a 38-Across story |
| 50% | INTHEBALLROOM | 13 | End of a possible solution in a game of Clue (3 wds.) |
| 50% | WITHTHEWRENCH | 13 | Second part of a possible solution in a game of Clue (3 wds.) |
| 50% | PROFESSORPLUM | 13 | First part of a possible solution in a game of Clue (2 wds.) |
| 50% | ORE | 3 | Metallic substance that's a resource in the game The Settlers of Catan |
| 47% | DESCENT | 7 | Start of a trip in a bathysphere |
| 47% | AISLE | 5 | One of a couple in a 767 |
| 47% | ACTS | 4 | Parts of a play in a theater |
| 47% | SQUASHRACKET | 12 | One of a pair in a court |
| 47% | FLAP | 4 | Sound of a sail in a gale |
| 47% | ZERO | 4 | One of a googol in a googolplex |
| 47% | SNUGNESS | 8 | Quality of a bug in a rug |
| 47% | HAY | 3 | Contents of a bale in a barn |
| 47% | ATTICSELLER | 11 | Proprietor of a store in a garret? |
| 47% | EGG | 3 | One of a dozen in a supermarket |
| 47% | EGG | 3 | One of a dozen in a carton |
| 47% | REP | 3 | Part of a set in a workout |
| 47% | JUROR | 5 | One of a dozen in a courtroom |
| 47% | SOLUTE | 6 | Substance in a chemistry experiment |
| 47% | FIBER | 5 | Substance in a bran muffin |
| 47% | OZONE | 5 | Substance in a stratospheric layer |