| 100% | NINE | 4 | Cost in dollars of the world's first TV ad in 1941 |
| 49% | BOSTON | 6 | Site of the world's first city marathon in 1897 |
| 42% | ATM | 3 | Installation of October 1997 in Canada's capital was the world's first talking one of these |
| 41% | ARNAZ | 5 | Surname of the baby on TV Guide’s first cover, in 1953 |
| 41% | LONDON | 6 | Site of the world's first subway |
| 41% | NAPLES | 6 | Site of the world's first pizzeria |
| 40% | PILE | 4 | Chicago ___-1, the world's first successful nuclear reactor, built under the west stands of the original Stagg Field in 1942 |
| 40% | SEIKO | 5 | Maker of the world's first quartz watch |
| 40% | DINAHSHORE | 10 | TV host in the World Golf Hall of Fame |
| 40% | ORCA | 4 | Apex predator in all of the world's oceans |
| 39% | MERCEDESBENZ | 12 | Maker of the world's first diesel-powered passenger car |
| 39% | MAUNALOA | 8 | The name of the world's largest volcano, in Hawaii |
| 39% | ALI | 3 | Sports Illustrated's Sportsman of the Year in 1974 (10 years after he first became world champion) |
| 39% | EYE | 3 | "The ___ of the World" (first novel in Robert Jordan's "The Wheel of Time" series) |
| 39% | TULIP | 5 | Flower that caused the world's first economic bubble in the 1630s |
| 39% | LANGTRY | 7 | Socialite Lillie who was one of the world's first celebrity endorsers |
| 38% | BBC | 3 | Largest TV network in the world, by number of employees |
| 38% | IKEA | 4 | Company that was the first in the U.S. to air a TV ad with a gay couple (1994) |
| 38% | DUBAI | 5 | Home of the world's tallest building, completed in 2009 |
| 38% | ELANA | 5 | ___ Meyers, who in 2015 was part of the first world champion team from the US in women's bobsled |
| 38% | HATH | 4 | Verb in the world's first telegraph message |
| 38% | OTTO | 4 | Cruise's ex in ''War of the Worlds'' |
| 38% | OTTO | 4 | Tom Cruise's ex in ''War of the Worlds'' |
| 38% | KENDALLJENNER | 13 | World's highest-paid model as of 2017, who first appeared in a reality TV show with her famous half-sisters: 2 wds. |
| 38% | DOHAQATAR | 9 | Locale of Stadium 974, the first temporary venue in World Cup history |
| 38% | YELLOWSTONE | 11 | The world's first national park, located in Wyoming, Montana, and Idaho |
| 37% | LOUISE | 6 | __ Brown, the world's first IVF baby, born in 1978 |
| 37% | ORCA | 4 | Whale found in every one of the world's oceans |
| 37% | CANADA | 6 | Most of the world's lakes are in this country |
| 37% | GAME | 4 | "___ of Thrones," TV series that will begin taking the world by storm in 2011 |