| 100% | ESL | 3 | Course whose S stands for "Second" |
| 67% | EOS | 3 | Lip balm brand whose S stands for "Smooth" |
| 55% | SSRI | 4 | Class of medication whose second "S" stands for serotonin |
| 51% | ASL | 3 | Its S stands for "Sign" |
| 48% | SAT | 3 | What S stands for in "SNL," for short |
| 48% | SOVIET | 6 | What the first S stood for in USSR |
| 45% | PRELAW | 6 | Course recommendation for one planning on standing in William Barr's shoes one day |
| 45% | IPA | 3 | Drink whose P stands for "pale" |
| 45% | MAC | 3 | Brand whose M stands for "makeup" |
| 45% | GNC | 3 | Abbreviation whose G stands for "gender" |
| 45% | FTC | 3 | Agency whose T stands for Trade |
| 45% | EDM | 3 | Genre whose D stands for "dance" |
| 45% | BMW | 3 | Company whose M stands for "Motoren" |
| 44% | SIERRA | 6 | It stands for S in the NATO phonetic alphabet |
| 44% | EPA | 3 | Org. whose E stands for Environmental |
| 44% | MILNE | 5 | Writer whose initials stood for Alan Alexander |
| 43% | NSA | 3 | Government org. whose name's second letter stands for the same thing as 22-Across's second letter |
| 42% | MLA | 3 | Citation style whose M stands for "Modern" |
| 42% | EDM | 3 | Music genre whose E stands for "electronic" |
| 42% | PTO | 3 | Workplace abbreviation whose P stands for "paid" |
| 42% | MRI | 3 | Hospital scan whose M stands for "magnetic" |
| 42% | MRT | 3 | TV star whose initial stands for Tureaud |
| 41% | IHOP | 4 | Restaurant whose "P" stands for "Pancakes" |
| 41% | IPA | 3 | Drink whose "I" stands for "India" |
| 41% | ORALB | 5 | Brand whose "B" stands for "brush" |
| 41% | BMW | 3 | Company whose "W" stands for "Werke" |
| 41% | STEM | 4 | Acronym whose "E" stands for "engineering" |
| 41% | SPACE | 5 | What "S" stands for in "NASA" |
| 41% | SOON | 4 | What "S" stands for in "ASAP" |
| 41% | SAINT | 5 | What "S" stands for in "YSL" |